BS or MS in Immunology, Immuno-Oncology, or related field.
0-5 years of experience in a biotech setting.
Experience with primary human T cell isolation and activation.
Familiarity with multicolor flow cytometry and data analysis tools.
Knowledge of standard molecular biology techniques, including PCR and Western blot.
Responsibilities
Package and titer lentivirus for CAR-T applications.
Design and execute in vitro functional assays to assess safety and potency.
Perform construct screening for CAR design optimization.
Handle and engineer human and murine T cells for research.
Maintain and engineer various cancer cell lines for model development.
Analyze and interpret experimental data, troubleshooting as necessary.
Maintain detailed experimental records for reproducibility.
Benefits
Health, dental, and vision insurance.
401(k) retirement plan with company match.
Paid time off and holidays.
Professional development opportunities.
Collaborative and innovative work environment.
Full Job Description
Senior Research Associate, Solid Tumor CAR-T
Role Overview
We are seeking a highly motivated Senior Research Associate to join our interdisciplinary cell therapy team at Legend Biotech, focused on advancing CAR-T cell therapies for solid tumors. This role will support our in vivo CAR-T platform, contributing to preclinical development from construct screening through animal model efficacy studies. You will work with the team to plan, execute, and troubleshoot experimental assays and laboratory methods, including cell-based functional and cytotoxicity assays, multi-color flow cytometry, ELISA and PCR-based assays, and viral vector packaging and titration.
The ideal candidate holds a BS or MS in Immunology, Immuno-Oncology, or a closely related discipline, with 0-5 years of experience in the biotech setting. You are a rigorous scientist who thrives in a fast-paced, collaborative environment and is passionate about translating basic immunology insights into transformative oncology therapies.
Key Responsibilities
Package and titer lentivirus
Design and execute in vitro functional assays for safety and potency
Perform construct screening for CAR design.
Handling and engineering human and murine T cells.
Engineering and maintaining various cancer cell lines for model development.
Analyze and interpret data, troubleshooting, maintain detailed experimental records.
Requirements
BS or MS.
A scientist in Immunology, Immuno-Oncology, Tumor Immunology, Cancer Biology, or a closely related field.
Candidates with experience in the biotech setting are strongly encouraged to apply.
Primary human T cell isolation, activation, lentiviral transduction, and expansion are required.
Familiarity with Incucyte, MSD, LDH release assay.
Multicolor flow cytometry: panel design, data acquisition (e.g., Attune, Novocyte, Cytek Aurora), and analysis (FlowJo).
Standard molecular biology: PCR/qPCR, lentiviral vector packaging and titration, Western blot.
High-throughput screening of drug candidates in the biotech setting.
Experience in cell-based assay development and troubleshooting.
Experience working with multiple immune cell types (T cell, B cell, myeloid) is a plus.
Knowledge in specific tumor disease area.
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Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.
About Legend Biotech Corporation
Legend Biotech Corporation is a clinical-stage biopharmaceutical company focused on developing innovative cell therapies for cancer. The company's lead product candidate, LCAR-B38M/JNJ-68284528, is a chimeric antigen receptor (CAR) T-cell therapy that is being developed for the treatment of multiple myeloma, a type of blood cancer. Legend Biotech was founded in 2014 as a subsidiary of GenScript Biotech Corporation and became an independent company in 2019. The company is headquartered in Shanghai, China and has operations in the United States and Europe.
