Job title: E4A Systemic Mastocytosis/Emerging Indication HEOR Strategy Specialist
Location: Cambridge, MA
Main Responsibilities This role will lead US-focused Health Economic and Outcomes Research activities for AYVAKIT® in Systemic Mastocytosis and emerging pipeline assets within the US Rare/Oncology HEVA team, providing US insights and executional leadership while remaining aligned to - but not accountable for - global HEVA strategy.
- Lead the design and execution of US-focused HEOR for AYVAKIT® (avapritinib) in Systemic Mastocytosis and assigned emerging assets - including economic modelling, database analysis, observational research, RWE studies, systematic literature review, evidence synthesis, and AMCP dossier development - setting US evidence generation priorities and incorporating them into broader Sanofi planning documents such as the Integrated Evidence Generation Plan (IEGP); operate with medium independence for strategic work and high independence for tactical execution, consistent with L3-2 expectations.
- Translate HEVA evidence into US business and policy impact by driving payer engagement, value positioning, and access strategies for AYVAKIT® in the US marketplace; understand and address US payer evidence requirements across managed care, specialty pharmacy, and rare disease payer dynamics; and support the development of compliant and impactful US evidence dissemination pathways (e.g., HCEI, PIE, CFL) including payer dossiers, field materials, and publications.
- Operate as part of a multi-functional US brand team responsible for designing research programs to meet the evidentiary standards of US reimbursement authorities and third-party payers; provide recommendations to ensure clinical and real-world evidence programs support US payer differentiation and value demonstration; and contribute to cross-functional US planning processes including brand planning, lifecycle management, and launch readiness for AYVAKIT® and pipeline assets.
- Serve as the US HEVA representative within the broader global HEVA team, ensuring the US perspective is well represented in global IEGPs, clinical development programs, and market access strategies; translate global evidence packages into US-specific value narratives and payer-facing materials; and engage with ICER review processes and the US policy landscape as relevant to Systemic Mastocytosis and emerging assets.
- Partner with US Medical Affairs, Value & Access, and Policy teams to ensure appropriate use of HEOR evidence in field communications, payer engagement, and training; collaborate on evidence that informs value frameworks, PDAB and ICER responses, and value-based contracting strategies; and mentor junior colleagues on a case-by-case basis, sharing US HEOR and market access expertise.
About YouBasic QualificationsEducation:- Advanced degree (PhD, PharmD, or equivalent) in health economics, epidemiology, public health, economics, or a related field; or Master's degree in a related field + minimum 4-5+ years of relevant HEOR/outcomes research experience
Experience:- Completion of a relevant fellowship or minimum of 2+ years of experience in health economics, outcomes research, or a related field
Technical Skills:- Foundational knowledge in health economic modeling, real-world evidence generation, evidence synthesis, and outcomes research methodologies.
- Understanding of global health technology assessment processes and payer decision-making frameworks.
- Foundational knowledge of AI and digital tools relevant to health economics, including familiarity with data analytics platforms and digital research tools; demonstrated willingness to rapidly develop proficiency with new digital and AI-enabled solutions.
Soft Skills:- Strong written and verbal communication skills with ability to present technical information clearly to diverse audiences
- Good project management skills with ability to manage timelines and deliverables while staying on budget
- Entrepreneurial spirit, team orientation, and ability to develop creative solutions to complex problems
Why Choose Us? - Bring the miracles of science to life alongside a supportive, future-focused team
- Discover opportunities to grow your talent and drive your career, whether through a promotion or lateral move, at home or internationally
- Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact
- Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs, and at least 14 weeks' gender-neutral parental leave
The salary range for this position is:
$148,500.00 - $214,500.00
All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
