Roche

Sr. Scientist - Translational PBPK Modeling

Roche$124K — $230K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • PhD in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or related field.
  • 2 years of relevant industry or post-doctoral experience in drug discovery/development.
  • Expertise in PBPK modeling and quantitative pharmacology.
  • Hands-on experience with modeling platforms like Simcyp, GastroPlus, or PK-Sim.
  • Strong communication and organizational skills.

Responsibilities

  • Strategize and plan PBPK modeling and simulations independently.
  • Execute and report PBPK modeling results.
  • Present findings at cross-functional teams and senior management reviews.
  • Represent DMPK at multi-functional discovery and development teams.
  • Lead DMPK strategy and design non-clinical studies.

Benefits

  • Domestic relocation assistance available.
Full Job Description

The DMPK department at Genentech is seeking a Ph.D. level Senior Scientist who is highly motivated to apply cutting edge translational modeling approaches to support the advancement of small molecule drug discovery and development projects. Physiologically-based Pharmacokinetic (PBPK) modeling will be a key focus of this position. Key technical responsibilities are to strategize, plan, execute, and report PBPK modeling and simulations independently, as well as to present work at cross-functional teams, department meetings, senior management review committees, regulatory interactions, and scientific conferences. Other responsibilities may also include representing DMPK at multi-functional discovery and development project teams and leading the DMPK strategy, including designing, executing and reporting non-clinical studies.

Who You Are

  • You hold a PhD in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or a related scientific field, paired with 2 years relevant industry or post-doctoral experience in drug discovery/development.

  • You bring expertise in PBPK modeling and quantitative pharmacology, with hands-on experience using platforms such as Simcyp, GastroPlus, or PK-Sim.

  • You demonstrate strong communication and organizational skills, with a track record of thriving within cross-functional team environments.

Preferred

  • Experience with additional modeling and simulation tools, such as Phoenix, R, NONMEM, SimBiology, Python.

  • Prior pharmaceutical industry experience as a DMPK project leader.

  • Experience supporting diverse modalities (small/large molecules, peptides, etc.) in drug development or modeling.

This position does offer domestic relocation.

The expected salary range for this position based on the primary location of San Francisco, CA is 124,300.00 - 230,900.00 USD. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

This position also qualifies for the benefits detailed at the link provided below.

About Roche

Roche Holding AG is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has bearer shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel. Roche is the largest pharmaceutical company in the world, and the leading provider of cancer treatments globally. The company also produces a range of diagnostic tests for medical professionals and patients. Roche was one of the first companies to bring targeted treatments to patients. In 2019, Roche had over 100,000 employees worldwide, and generated revenue of CHF 61.5 billion.
Learn more about Roche
Size
100,920 employees
Industry
NASDAQ

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