The RoleThe Senior Research Associate, high-throughput (HTP) RNA production, serves an important role in generating RNAs to advance Sail's first-in-class programmable circular RNA technology (Endless RNA™ or eRNA). This role will carry out end-to-end process of high-throughput RNA production, from template plasmid cloning to RNA generation and clean up. The successful candidate is organized, attentive to details, a fast learner with a strong sense of responsibility who takes pride in his/her work. The team looks forward to helping you strive in this exciting and fast-paced environment to make a real-world impact on patients' lives.
Responsibilities - Perform high-throughput cloning of plasmid constructs and RNA generation through in vitro transcription (IVT)
- Determine circularization efficiency and impurity levels by running analytic assays
- Coordinate DNA synthesis and scale-up orders with external vendors
- Manage raw material and RNA inventories
- Collaborate with automation engineer to improve process workflow
- Maintain detailed documentation in electronic lab notebooks
- Present findings clearly to platform teams and contribute to scientific discussions and decision-making
Qualifications- B.S. in Life Sciences, Chemistry, Engineering, or a related field with 2+ years of relevant full-time industry or academic research experience, or M.S. in Life Sciences
- Ability to manage multiple tasks at once efficiently
- Strong collaborative spirit and communication skills
- Excellent record keeping
Preferred Qualifications- Experience in molecular biology including cloning, RNA production and purification
- Familiarity with high-performance liquid chromatography (HPLC) or other column-based purification/analytic methods
- Experience with automated liquid handling systems (e.g., Hamilton) and high-throughput laboratory workflows
- Experience using data analysis and information management tools, such as Excel, Graphic Prism, SnapGene, Benchling
- Experience in inventory management
Salary Range: $75,000 - $95,000
