Description
We are seeking a Senior Principal/ Principal Scientist, Computational Safety, to provide scientific leadership in in silico safety assessment across drug discovery and development. This role will leverage advanced multi omics data, systems toxicology and AI/ML approaches to proactively identify safety liabilities, support mechanistic understanding, improve quality target identification, and facilitate risk based decision making.
The Senior Principal Scientist/ Principal will play a key role in developing and delivering integrated computational safety strategies, including AI enabled foundation model based on multiple omics data, Adverse Outcome Pathways, off-target identification, and predictive liability models. Working closely with toxicologists, discovery scientists, clinical safety, bioinformatics, data science, and IT partners, this position will translate complex computational insights into clear, actionable recommendations that improve pipeline quality and reduce late stage attrition.
Duties & Responsibilities
• Lead and/or generate in silico target safety assessment strategy development
• Develop and deliver integrated computational safety packages to support program and portfolio decisions
• Advance AI/ML and multi omics-based models, including foundation models, for safety and liability prediction
• Drive AI enabled Adverse Outcome Pathway (AoP) development to support mechanistic risk assessment
• Proactively identify and communicate on target and off target safety risks
• Collaborate closely with Toxicology, Discovery, Clinical Safety, Bioinformatics, Data Science, and IT teams
• Serve as a bridge and clearly communicate complex computational insights to multidisciplinary stakeholders.
Requirements
Principal Scientist Requirements:
• 6+ years of post-doctoral and/or industry experience in drug discovery and development and 61 years of experience in safety risk assessment is a must
Senior Principal Scientist Requirements:
• 7+ years of post-doctoral and/or industry experience in drug discovery and development and 63 years of experience in safety risk assessment is a must
Requirements for both levels
• Ph.D. in Computational Toxicology, Computational Biology, Bioinformatics, Molecular Biology, or related field
• Strong collaboration, scientific leadership, and communication skills, with the ability to translate complex computational results into actionable insights for stakeholders with diverse backgrounds
• Expertise in computational toxicology, AI/ML modeling, and multi-omics (TGx) data integration
• Experience with in silico safety, liability prediction, and mechanistic modeling
• Familiar with toxicology related data curation, and interpretation, and knowledge of GLP toxicology and regulatory guidance will be a favorable plus
Eligibility Requirements
• Must be legally authorized to work in the United States without restriction.
• Must be willing to take a drug test and post-offer physical (if required)
• Must be 18 years of age or older
@computationalinnovation
Compensation Data
The base salary range for the Scientist II position is $140,000 to $222,000.
The base salary range for the Scienitst III position is $170,0000 to $269,000.
The position may be eligible for a role specific discretionary bonus, relocation, and/or other compensation elements. We continuously review market data and may adjust salary ranges as needed in the future. Actual compensation will be based on job-related factors such as skills, experience, and qualifications, and other factors permitted by law. For an overview of our benefits please click here .
