Your Impact at LILAThe Life Science AI team develops machine learning systems for automated reasoning on biological data, combining state-of-the-art ML with breakthrough biology. We seek a Senior ML Scientist to focus on domain models underneath that system: models of perturbation biology, genetics, and and high-dimensional experimental readouts that connect biological mechanism, experimental intervention and therapeutic opportunity.
At Lila, the data is generated for the model: we run our own experiments at scale, and you will help decide what gets measured. The question is not only what to learn from a fixed dataset, but what datasets should exist. And model outputs are reasoned over. Predictions go to systems and scientists choosing what to run next and making mechanistic calls downstream. Both need to know why, not only what. A model that returns a quantity a biologist, human or AI, can argue with; models that transfer to new contexts, compose into a downstream calculation, and can be checked against an independent measurement are often worth more than a more accurate one that returns an embedding.
What You'll Be Building- Build domain models for perturbation, genetic, and multimodal experimental data, and translate biological questions into rigorous ML problem formulations. Where the biology supports it, build models with interpretable structure - representations grounded in the machinery that executes a biological process rather than in cell-type identity embeddings, and parameters a biologist can argue with.
- Make uncertainty a deliverable. Calibrated posteriors, honest error bars, and outputs that tell a downstream consumer how much a prediction can actually settle - particularly when predicting into conditions never measured.
- Pre-register and beat baselines. Simple entity-mean, additive, and linear baselines are stated before any model is fit. If the full model does not beat them, we ship the baseline and say so.
- Partner with experimental scientists to guide data generation and model validation - shaping what gets measured, in what contexts, at what precision - and build the experiment-selection methods that choose the next batch of measurements to reduce uncertainty where it matters.
- Design benchmarks that connect model performance to biological and therapeutic consequence, apply model outputs to prioritize targets and mechanisms, and contribute technical direction to high-impact modeling programs.
- Support the integration of domain models into agentic workflows. Deploy tools, help engineer the agent harnesses that incorporate these tools and collaborate on creating environments to train the reasoning models that drive these agents.
What You'll Need to Succeed- PhD in machine learning, statistics, computational biology, computer science, bioengineering, physics, or a related quantitative field, with a strong publication record or equivalent industry impact.
- Experience developing models for high-dimensional biological data, and the judgment to connect ML methods to biological mechanism and experimental design.
- Generalization under structured sparsity. A track record of building models that predict into conditions not directly observed - sparse or unbalanced experimental designs, held-out combinations, transfer to new contexts - rather than interpolating within a densely sampled corpus.
- Uncertainty and evaluation rigor. Comfort with calibration, proper scoring rules, and evaluation design, in work where someone made a decision based on your numbers.
- Strong programming skills, reliable ML research workflows, and clear communication across ML, biology, and experimental teams. Track record of leading ambiguous research problems from formulation through execution.
- Communicate findings clearly to technical and cross-functional audiences, including scientists, engineers, product partners, and therapeutic stakeholders.
- Support external scientific visibility through publications, presentations, and engagement with ML/AI for Biology, computational biology and therapeutic discovery communities, as appropriate.
Bonus Points For- Mechanistic and probabilistic modeling - the strongest differentiator for this role. Bayesian hierarchical models, simulation-based or likelihood-free inference, amortized posterior inference, state-space or ODE-based models, neural differential equations, or mechanism-informed ML. Also relevant from outside biology: pharmacokinetic/pharmacodynamic, systems-biology, or physical modeling where the parameters had to mean something.
- Experience with models in at least one of these areas:
- Familiarity with active learning, Bayesian optimal experimental design, closed-loop experimentation, or lab-in-the-loop systems.
- Experience deploying research models into scientific decision-making workflows, including serving models as tools other systems call.
CompensationWe offer competitive base compensation with bonus potential and generous early-stage equity. Your final offer will reflect your background, expertise, and expected impact.
U.S. Benefits. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.
International Benefits. Full-time employees outside the U.S. receive a comprehensive benefits program tailored to their region. USD salary ranges apply only to U.S.-based positions; international salaries are set to local market.
Expected Base Salary Range
$268,000-$358,000 USD
