JOB SUMMARYPlans, coordinates, directs, and participates in work of smaller research project or major unit of large research project in field of specialization for which incumbent is particularly qualified in terms of extensive training and and/or experience.
The Vascular-Immunology Laboratory of Laurel Y. Lee, MD, DPhil in the Division of Cardiology at UT Southwestern Medical Center is seeking a highly motivated Research Scientist to join our expanding basic and translational research program. Working within a world-class academic environment, the Research Scientist will assist with planning and executing bench research and mouse work aimed at understanding the mechanisms underlying immune-mediated vascular disorders and identifying novel therapeutic targets.
The ideal candidate will possess deep technical expertise and experience in both bench-based molecular and cell biology techniques and mouse experiments. This position will also be responsible for managing laboratory operations and training and mentoring students, postdoctoral fellows, and junior laboratory personnel.
Key Responsibilities:
- Under the principal investigator's direction, plan, execute, and troubleshoot complex in vitro and in vivo experiments.
- Experimental approaches will include but not limited to mammalian cell culture; mouse cardiac perfusion and vascular tissue harvest; molecular biology (RNA/DNA extraction, PCR, QPCR, western blot, CRISPR/Cas9 gene editing, transfection and sequencing); flow cytometry; histology; advanced imaging analysis and quantification; metabolomics analysis
- Analyze and interpret data using statistical methods and prepare data figures/tables and written summaries for the principal investigator's review while maintaining accurate and timely laboratory notebooks and research records on a daily basis.
- Manage mouse colony with breeding and genotyping and perform mouse treatments and/or surgery as part of in vivo experiments
- Manage lab operations with the responsibilities including but not limited to maintaining well-organized lab supply inventories, reagent ordering, equipment maintenance, and maintaining and updating the lab safety protocols and animal protocols while maintaining a clean and functional workspace and a respectful and inclusive environment.
- Assist with selecting, training and supervising junior lab personnel, including students, technicians, and postdoctoral fellows as directed by the principal investigator
- Develop and maintain standard operating protocols for experiments for the lab
- Perform other duties as assigned by the principal investigator
Preferred Qualifications:
- Ph.D. in biomedical sciences, molecular biology, immunology, cardiovascular biology, or a closely related field
Proficiency in mouse handling, breeding, genotyping, and tissue harvesting with a minimum of one year of proven hands-on experience
Proficiency in routine molecular and cellular biology techniques, including but not limited to RNA and protein extraction, PCR, QPCR, western blot, and cell culture - Proficiency in data analysis and figure preparations for publication
- Strong track record of publications in peer-reviewed scientific journals
- Excellent organization skills
- Excellent written and oral communication skills
- Demonstrated ability to work effectively across interdisciplinary teams
- Proficiency with flow cytometry
BENEFITSUT Southwestern is proud to offer a competitive and comprehensive benefits package to eligible employees. Our benefits are designed to support your overall wellbeing, and include:
- PPO medical plan, available day one at no cost for full-time employee-only coverage
- 100% coverage for preventive healthcare-no copay
- Paid Time Off, available day one
- Retirement Programs through the Teacher Retirement System of Texas (TRS)
- Paid Parental Leave Benefit
- Wellness programs
- Tuition Reimbursement
- Public Service Loan Forgiveness (PSLF) Qualified Employer
- Learn more about these and other UTSW employee benefits!
EXPERIENCE AND EDUCATIONRequired- Education
PhD with major course work in the field of assignment or
Master's Degree with major course work in the field of assignment or
Bachelor's Degree with major course work in the field of assignment
- Experience
5 years of research experience in the field of assignment with PhD including
2 years at the level of Senior Research Associate or its equivalent or
7 years of research experience in the field of assignment with Master's degree including
3 years at the level of Senior Research Associate or its equivalent or
9 years of research experience in the field of assignment with Bachelor's degree including
4 years Level of Senior Research Associate or its equivalent.
JOB DUTIES- Plans, organizes coordinates, directs, and personally participates in assigned scientific or medical research project. Selects or assists in selection of key research personnel. Determines specific goals or objectives to be attained. Assigns and reviews work of subordinates. Plans experimental protocols.
- Reviews and analyzes resulting research data. Revises techniques or approaches to work problems as indicated necessary by research data.
- Compiles, writes, and submits research results to supervisor. Prepares or assists in preparation of research papers, reports, and abstracts for publication as one of co-authors.
- Designs, develops, or adapts equipment used in experiments or research to obtain desired results.
- Plans and supervises training of technicians and other laboratory personnel with respect to proper laboratory techniques, use of laboratory equipment, and safety procedures.
- Supervises group of employees of lower grade engaged in performance of technical and professional work, which vary from routine to complex laboratory work tasks.
- May confer with industrial, governmental, or other groups concerning progress or results of research project.
- Performs other duties as assigned.
