Job title: Process modelling (Protein/Antigen) Principal Data Scientist
Location: Waltham, MA
Main Responsibilities • Lead the development and deployment of AI, machine learning, mechanistic, and hybrid modeling solutions to accelerate recombinant protein vaccine process development and manufacturing.
• Apply advanced analytics to identify critical process parameters, predict product quality, improve yield, and optimize process performance.
• Develop modeling solutions for upstream processes, including CHO cell culture, baculovirus and insect cell expression systems, and cell line development.
• Support optimization of downstream purification operations, including chromatography, filtration, and ultrafiltration/diafiltration, through data-driven and model-based approaches.
• Build and deploy digital twins, simulation tools, and decision-support frameworks to support process optimization, scale-up, technology transfer, and lifecycle management.
• Collaborate with process development, analytical sciences, manufacturing, and digital teams to integrate process knowledge and data into actionable insights.
• Provide scientific leadership and mentorship in AI, machine learning, data science, and process modeling across the organization.
About You Basic QualificationsEducation- Ph.D. in Chemical Engineering, Bioengineering, Biotechnology, Computational Biology, Data Science, Applied Mathematics, or a related scientific discipline
Experience- 2+ years of relevant experience in the pharmaceutical industry
Preferred Qualifications- Background applying data science, machine learning, and process modeling in biopharmaceutical, biologics, vaccine, or related development environments, including recombinant protein production and manufacturing.
- Expertise in AI, machine learning, multivariate data analysis, mechanistic and hybrid modeling, digital twins, process simulation, Bayesian optimization, and Design of Experiments, including model-based approaches.
- Experience supporting CHO cell culture, baculovirus expression systems, protein purification, and/or cell line development
- Proficiency in scientific computing and modeling platforms such as Python, R, MATLAB, JMP, gPROMS, GoSilico, or equivalent tools
- Strong scientific leadership, problem-solving, communication, and cross-functional collaboration skills.
Languages: Fluent English required.
The salary range for this position is:
$122,250.00 - $176,583.33
All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
