The PositionAre you a driven and passionate scientist with a strong scientific background in Obesity related comorbidities, such as MASH or CVD? Do you wish to help shape our research initiatives and contribute to the development of life-changing therapies? Look no further! Our company is seeking a highly motivated Principal Scientist to join our Emerging Obesity Mechanisms research team as part of the US Obesity Research Department.
As a Principal Scientist, you will be responsible for executing and delivering on our Obesity and Cardiometabolic Comorbidities portfolio and be considered a disease expert. You will be involved in leading and championing target data packages from discovery through IND submissions for our US-based Obesity Research department.
RelationshipsReports to the Director of Emerging Obesity Mechanisms at Novo Nordisk in Massachusetts. Internal relationships include working closely with technical staff & other members of the Obesity Research US leadership team. Additionally, regular collaborations with members of other research departments & frequent interaction with project managers, project leads, governance leadership, and other colleagues across global R&D. Individual may indirectly mentor less experienced team members. Individuals may interact with external research collaborators in both academia and industry.
Essential Functions- Serve as a biology and disease-area expert for MASH and obesity-related comorbidities focused on peripheral organs (CVD and emerging "feel & see" indications like osteoarthritis, sleep apnea, muscle preservation as defined by portfolio strategy).
- Lead target identification, validation and maturation of novel obesity-comorbidity targets from idea generation through pre-clinical and clinical-stage gates across small-molecule and RNAi/siRNA modalities.
- Build and strengthen the mechanism-of-action narrative and assemble the scientific rationale, data packages and screening plans required for governance review to accelerate progression toward first human dose / IND submission.
- Provide cross-functional and cross-site scientific leadership, coordinating biology activities with pharmacology, digital biology/omics, and Denmark-based counterparts, and communicating clearly with project teams and stakeholders on strategy, unmet need and priorities.
- Cultivate and manage external academic and biotech collaborations to in-source targets/assets, de-risk mechanisms and extend capabilities across MASH and broader obesity comorbidities, in line with the site's goal of extracting greater value from external innovation.
- Drive scientific communication through publications, participation at conferences, and building external interactions with Key Opinion Leaders as assets advance.
- Mentor and upskill junior scientists towards scientific autonomy and leadership capabilities needed to progress and champion targets through the broader Obesity pipeline
- Champion human-centric, fit-for-purpose drug discovery by prioritizing primary human cells, patient-relevant in vitro systems, and multi-omics-informed disease modelling to strengthen translational relevance
- Bring deep receptor-pharmacology and mechanism-of-action expertise to build robust, translatable MoA-based datasets across small-molecule and RNAi modalities.
Qualifications- Bachelor's degree required. Relevant Post-graduate or industry experience required
- 22+ years' relevant experience required, Master's Degree with 16 years relevant industry or post-doctorate experience can be considered. PhD with 10 years relevant industry or post-doctorate experience can be considered
- Relevant required experience includes: insert subject matter expertise
- Preferred experience includes: insert subject matter preferred experience
- Demonstrates excellent verbal and written communication skills
The base compensation range for this position is $180,000 to $235,000. Base compensation is determined based on a number of factors. This position is also eligible for a company bonus based on individual and company performance. Novo Nordisk offers long-term incentive compensation and or company vehicles depending on the position's level or other company factors.
Employees are also eligible to participate in Company employee benefit programs including medical, dental and vision coverage; life insurance; disability insurance; 401(k) savings plan; flexible spending accounts; employee assistance program; tuition reimbursement program; and voluntary benefits such as group legal, critical illness, identity theft protection, pet insurance and auto/home insurance. The Company also offers time off pursuant to its sick time policy, flex-able vacation policy, and parental leave policy.
