Role Location: Waltham, MA
About the Role at Alloy TherapeuticsAs Head of Cell Line Development, you will lead technology evaluation, development, and strategy for stable cell line technologies. This is a senior leadership role responsible for shaping the scientific and technical direction of our cell line development capabilities, ensuring we remain at the forefront of innovation in stable transfection, clone selection, and cell line engineering.
This role will report directly to the CEO of the Antibody Powered Division in Waltham, MA, with autonomy owning various stakeholders, projects, and tasks in a dynamic start-up environment while keeping up the pace of Alloy.
How You'll Drive Impact- Drive: Scientific direction and execution of cell line technology development projects.
- Innovate: Ensure the application of cutting-edge technologies and methodologies in cell line engineering.
- Collaborate: Integrate cell line development product offerings and engage with external collaborators in preparation of manufacturing of biologics.
- Deliver: Efficient execution of partner projects balancing quality, timelines, and costs, while ensuring successful completion of cell line producution that meet our partners' objectives.
- Lead: Marshall, inspire, and mentor a cross-functional team of scientists. Lead by example by going the extra mile to ensure we are successful delivering on projects.
- Communicate: Communicate effectively with key stakeholders externally and internally, fostering productive interactions both upward and downward, and across teams at different sites.
Key Responsibilities- Lead technology evaluation and development strategy for stable cell line platforms, including host cell engineering, vector design, transfection methods, and clone screening/selection technologies
- Identify, assess, and implement next-generation technologies for stable transfection and cell line generation to improve titer, stability, product quality, and speed to clinic
- Set scientific strategy and roadmap for cell line development capabilities in alignment with broader organizational goals
- Stay current on emerging trends in stable cell line technologies (e.g., targeted integration, site-specific recombination, novel selection systems, high-throughput single-cell cloning, and next-gen expression platforms) and evaluate their applicability
- Represent the organization's cell line development capabilities in interactions with clients, partners, and at scientific conferences
- Develop and oversee IP strategy related to proprietary cell line technologies
- Ensure development activities meet relevant regulatory expectations (e.g., ICH Q5D) and support regulatory filings as needed
- Manage budgets, timelines, and resource allocation for cell line development programs
Required Qualifications - Ph.D. in Cell Biology, Molecular Biology, Biochemical Engineering, or a related field
- 10+ years of hands-on experience in cell line development within a CDMO or pharmaceutical/biotech company setting
- Demonstrated proven track record of successfully developing and advancing stable mammalian cell lines (e.g., CHO) for biologics production
- Deep familiarity with current and emerging technologies for stable transfection and cell line generation (e.g., electroporation, lipofection, viral-mediated delivery, targeted integration systems, novel selection markers, high-throughput clone screening platforms)
- Strong understanding of clone selection, cell banking, stability testing, and characterization requirements (including regulatory expectations such as ICH Q5D)
- Experience leading teams and managing complex, multi-stakeholder technical programs
- Excellent communication skills, with experience presenting to internal leadership, clients, and/or regulatory bodies
Preferred Qualifications- Prior experience evaluating or implementing novel cell line development platforms (e.g., targeted integration systems, next-generation expression vectors, single-cell dispensing/imaging technologies)
- Experience with GMP-regulated environments and technology transfer to manufacturing
- Track record of publications, patents, or conference presentations in cell line development
- Experience in a client-facing CDMO environment
Taking Care of Our PeopleWe support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you're single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.
Compensation
- Competitive base and equity compensation commensurate with level of experience and independence
- 401(k) company match
Health & Family
- Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
- Company-paid disability (STD, LTD) and life insurance
- Paid parental leave
- Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)
Unique Perks
- Unlimited PTO (paid time off) and flexible schedules
- Annual stipend for continuing education with commitment to your career through individualized professional development plan
- Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness
Pay TransparencyAt Alloy Therapeutics, we believe in fostering trust and open communication. For this role, the estimated range is $150,000 - $215,000, with the final offer based on factors like your experience, skills, and alignment with our needs.
Additionally, this role is eligible for equity compensation, reflecting our commitment to shared success as we work together to make better medicines.
We are proud to offer competitive compensation and benefits, aiming to support our team's professional and personal well-being. If you have any questions about pay or benefits, we're here to help.
