Master's degree in Molecular/Cellular Biology, Biochemistry, or related field with 3 years of relevant experience, or Bachelor's degree with 5 years of relevant experience.
Experience in RNA therapeutics, specifically pre-mRNA splicing and protein translation.
Proficiency in designing and cloning RNA exon-editing molecules.
Skilled in designing assays to measure RNA editing and optimizing custom Illumina libraries.
Familiarity with bioinformatic analysis of sequencing libraries.
Responsibilities
Design and validate experiments to enhance therapeutic performance of RNA editing molecules.
Execute and interpret experiments related to drug candidate characterization.
Contribute to the Roche Collaboration by supporting experimental design and execution.
Optimize and prepare custom Illumina libraries for RNA analysis.
Conduct bioinformatic analysis and data interpretation of experimental results.
Benefits
Collaborative work environment with a focus on innovative RNA therapeutics.
Opportunity to contribute to high-impact projects in partnership with Roche.
Access to advanced technologies and methodologies in molecular biology.
Professional development opportunities in a cutting-edge field.
Full Job Description
(Boston, MA) Principal Associate Scientist sought by Ascidian Therapeutics, Inc. to design, validate, execute, and interpret experiments to improve therapeutic performance of designer RNA editing molecules & contribute to characterization of drug candidates to support Ascidian's Roche Collaboration. Req.'s Master's Deg. in Molecular/Cellular Bio., Bio. Chem. or rel. field & 3 yrs rel. exp. or Bach's Deg. & 5 yrs rel. exp. Must have experience in RNA therapeutics with a focus on pre-mRNA splicing and protein translation; designing and cloning RNA exon-editing molecules and designing assays to measure RNA editing; optimization and preparation of custom Illumina libraries; bioinformatic analysis of the libraries; cell culture, ddPCR, qPCR and protein extraction and characterization by JESS and western blot, Sanger sequence analysis; use of sequence design and analysis software.
No calls.
Salary: $ 112,017 to $118,400 per year.
The final salary offer will be determined based on several factors, including the candidate's relevant experience, specific skills, and internal equity.
