Full Job Description
Join our global Analytical Development and Quality Control team as a Technical DevelopmentPrincipal Scientist, Mass Spectrometry Characterization Lead, driving analytical strategies that transform cutting-edge biologic therapeutics from early development to commercialization. In this role, you will bridge strategic leadership with hands-on laboratory expertise within a collaborative, multidisciplinary environment dedicated to delivering life-changing medicines. You will lead mass spectrometry characterization, solve complex analytical challenges, and guide cross-functional teams with scientific excellence and impact.
The Opportunity
• Lead the mass spectrometry (MS) characterization strategy and execution across all stages of biologic therapeutic development, from early development through to commercial launch.
• Design, execute, and interpret complex liquid chromatography-mass spectrometry (LC-MS) analyses to establish deep structural understanding of protein modalities and resolve technical root causes.
• Develop and implement phase-appropriate MS methods and advanced multi-attribute method (MAM) strategies where standard analytical assays fall short.
• Identify, monitor, and quantify critical quality attributes (CQAs) and post-translational modifications (PTMs) to ensure reliable analytical control.
• Support process development milestones, including cell line selection, purification, formulation, stability, minor variant characterization, and structure-function elucidation.
• Author filing-ready MS characterization sections for global regulatory submissions (IND, BLA, and MAA) and represent technical packages in regulatory interactions.
• Collaborate closely with multidisciplinary teams, analytical leads, and external research/manufacturing partners to achieve project delivery milestones.
• Mentor scientific team members in MS data interpretation and champion modern analytical capabilities and best practices.
Who you are
• You hold a Ph.D. with 4–6+ years of relevant experience, or an M.S./B.S. with 6–10+ years of experience in Analytical Chemistry, Biochemistry, Chemical Engineering, or a related field.
• You bring deep analytical expertise in liquid chromatography-mass spectrometry (LC-MS) applied to the characterization of proteins or related therapeutic modalities.
• You possess strong working knowledge of chemistry, manufacturing, and controls (CMC) drug development and regulatory filing processes (IND/BLA).
• You demonstrate excellent collaborative, organizational, and communication skills, thriving both as an independent lead and as part of a dynamic, multidisciplinary team.
• You are an agile problem-solver motivated by scientific curiosity, technical quality, and delivering meaningful results in a fast-paced environment.
Relocation benefits are available for this job posting.
The expected salary range for this position based on the primary location of South San Francisco, CA is $120,800 - $224,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
