PhD or equivalent in pharmacokinetics, pharmacology, biochemistry, or related field
8+ years of industry experience in DMPK or a closely related function
Working knowledge of bioanalytical methods (e.g., LC-MS/MS, ligand binding assays, NGS)
Demonstrated CRO oversight including vendor qualification and study monitoring
Experience designing and overseeing in vivo nonclinical PK and PK-PD studies, preferably with LNP
Hands-on experience with PK and PK-PD data analysis using software like Phoenix WinNonlin
Strong scientific writing skills for regulatory documents and internal reports
Responsibilities
Lead DMPK strategy and oversee bioanalytical work across nonclinical and clinical programs
Oversee development, qualification, and validation of bioanalytical assays and sample analysis
Design, execute, and oversee PK and PK-PD studies to evaluate delivery technologies
Lead PK and PK-PD data analysis across various species to support dose selection
Manage and qualify CRO and external lab partners for bioanalytical and PK programs
Support nonclinical toxicology programs in collaboration with internal teams and CROs
Analyze and present DMPK and biomarker data to leadership and stakeholders
Author nonclinical sections of regulatory filings and support agency interactions
Benefits
Healthcare coverage
Annual incentive program
Retirement benefits
Broad range of other benefits
Full Job Description
Reporting to the Chief Scientific Officer, this role leads DMPK strategy and oversees bioanalytical work across nonclinical and clinical programs, operating as a hands-on scientific leader. We are looking for an accomplished DMPK scientist with experience in PK and PK-PD study design, PK data analysis and interpretation, and translational biomarker strategy. This person will support pharmacology and nonclinical toxicology programs, providing broader context across the nonclinical development portfolio. The ideal candidate brings deep scientific expertise and a hands-on approach and thrives in the fast-paced environment of a clinical-stage biotech where both scientific and strategic contributions are expected.
Responsibilities
Lead DMPK strategy and oversee bioanalytical work across nonclinical and clinical programs, including PK, biomarker, and translational PD readouts
Oversee development, qualification, and validation of nonclinical and clinical bioanalytical assays (GLP/GCP-compliant as required), as well as sample analysis, working with internal and CRO analytical scientists
Design, execute, and oversee PK and PK-PD studies of tRNAs to evaluate delivery technologies (LNP and others), biodistribution, and biomarker effects
Lead PK and PK-PD data analysis and interpretation across mouse, rat, NHP, and human studies to support dose selection
Manage and qualify CRO and external lab partners across bioanalytical and PK programs
Support nonclinical toxicology programs in collaboration with internal teams and CROs
Analyze, interpret, and present DMPK and translational biomarker data to internal leadership and external stakeholders
Author nonclinical sections of regulatory filings (e.g., IND) and briefing documents; support agency interactions and responses
Serve on the Research Leadership Team; represent DMPK and bioanalytical sciences in cross-functional program discussions
Manage and develop direct report(s); collaborate with the broader pharmacology team
Required Qualifications
PhD or equivalent in pharmacokinetics, pharmacology, biochemistry, or related field
8+ years of industry experience in DMPK or a closely related function
Working knowledge of bioanalytical methods (e.g., LC-MS/MS, ligand binding assays, NGS) sufficient to oversee their development, qualification, and validation and the associated sample analysis in nonclinical and clinical contexts
Demonstrated CRO oversight - vendor qualification, study monitoring, data review
Experience designing and overseeing in vivo nonclinical PK and PK-PD studies for novel delivery modalities; LNP experience preferred
Hands-on experience with PK and PK-PD data analysis (e.g., noncompartmental analysis) and associated software (e.g., Phoenix WinNonlin), applied to the design and interpretation of nonclinical and clinical studies
Experience in translational or clinical biomarker development, including assay strategy and fit-for-purpose qualification
Strong scientific writing skills - regulatory documents (e.g., IND nonclinical sections) and internal study reports
Experience supervising and developing scientists
Preferred Qualifications
Experience in rare disease or genetic medicine
Experience with RNA-based therapies
Familiarity with LNP platform biology and delivery landscape
Familiarity with GLP toxicology study design and ICH nonclinical guidelines
Experience operating in a cross-functional leadership role at a clinical-stage biotech
Experience with ligand binding assays and multiplex immunoassay platforms (e.g., MSD, Luminex) for cytokine, immunogenicity, and biomarker analysis
The salary range for this role is $81,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Alltrna currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Alltrna's good faith estimate as of the date of publication and may be modified in the future.
