Merck & Co, Inc

Senior Director, Oncology Small Molecule

Merck & Co, Inc$194K — $305K *
Pharmaceuticals & Biotech
8 - 10 years of experience
Job Overview by Ladders

Qualifications

  • Ph.D. in relevant STEM field with 10+ years of post-degree industry experience.
  • Extensive background in cancer biology, translating insights into drug development.
  • Innovative small molecule design experience, specifically in induced proximity.
  • Track record of advancing small molecule candidates successfully to clinical stages.
  • Hands-on experience with IND submissions and regulatory interactions.
  • Experience leading senior and junior scientists within multidisciplinary teams.

Responsibilities

  • Develop and execute a comprehensive pipeline strategy for Oncology small molecules.
  • Serve as a strategic thought leader in small molecule therapeutics.
  • Evaluate new therapeutic opportunities utilizing a deep understanding of cancer biology.
  • Provide oversight for the transition of programs from discovery to late-stage development.
  • Drive key milestones from candidate selection to IND-enabling studies and clinical support.
  • Lead business development evaluations from a scientific view, identifying external assets.
  • Contribute to team strategy and staff development as part of the Discovery Oncology Leadership.

Benefits

  • Medical, dental, and vision healthcare options for employees and families.
  • Retirement benefits including a 401(k) plan.
  • Paid holidays, vacation, as well as compassionate and sick days.
  • Access to annual bonuses and long-term incentives, if applicable.
Full Job Description

Job Description

The successful candidate will lead a team at our company's Boston site delivering on the small molecule Oncology pipeline. They will be the strategic leader for Oncology small molecule therapeutics in Boston, with opportunities to contribute across additional modalities. They will develop and execute a comprehensive pipeline strategy, partnering across our company to expand our portfolio. This leader will work tightly with chemistry, clinical, translational, and business development to build and progress an effective pipeline of compelling medicines, from discovery through late-stage development. The successful candidate will have a strong record of scientific excellence, thoughtful strategic planning, late-stage research and IND experience, and inspiring people leadership.

Responsibilities

  • Develop and execute a forward-thinking pipeline strategy, shaping the future of our Company's Oncology therapeutics with a focus on small molecules.

  • Be a strategic thought leader for the employment of small molecules to create effective, tolerable, and combinable medicines that are both first-in-class and best-in-class.

  • Leverage your deep understanding of cancer biology (including intrinsic pathways and key cancer drivers) and the current internal and external oncology landscape to evaluate the opportunity of new therapeutics and drive portfolio decisions.

  • Provide strategic oversight for programs as they transition from early discovery into and through late-stage clinical development, ensuring continuity and alignment with the overall asset strategy.

  • Drive key milestones for pipeline advancement, from preclinical candidate selection through to IND-enabling studies and support for early clinical development. Ensure compelling engagement with regulatory agencies.

  • Lead business development evaluations from a scientific perspective, identifying and championing external assets and platforms that align with our strategic vision.

  • As a member of the Discovery Oncology Leadership team, meaningfully contribute to the development and execution of strategy and the growth and development of staff. Act as an experienced Program Lead and mentor others to become strong Program Leaders.

  • Foster a high-performance culture of collaboration, engagement, self-accountability, and inclusion. Establish strong relationships within highly collaborative, multidisciplinary teams to effectively drive drug discovery initiatives.

Required Qualifications / Education:

  • Ph.D. in Biology, Oncology, Pharmacology, Biochemistry, Toxicology, Biophysics, Immunology, or a related STEM subject area with 10+ years of post-degree experience in industry or equivalent.

  • An extensive background in cancer biology with a proven ability to translate deep scientific insights into drug development strategies from discovery through late-stage development.

  • Evidence of innovative approaches to small molecule design, particularly induced proximity.

  • A proven track record of successfully advancing multiple well-designed investigative small molecule drug candidates into the clinic, with a focus on patient experience and successful clinical execution.

  • Clear experience in late program leadership partnering with regulatory, translational sciences, and clinical development. Direct, hands-on experience writing IND modules and filings.

  • Experience managing a group of senior and junior scientists with a track record of achievements, including project leadership and strategic contributions.

  • Ability to build strong relationships within highly collaborative, multidisciplinary teams to effectively drive drug discovery initiatives.

  • Excellent attention to detail and strong communication (oral and written) skills.

  • Highly self-motivated and capable of prioritizing deliverables.

Preferred Experience and Skills:

  • Preference will be given to candidates with a large breadth of small molecule experience, including novel approaches.

  • Experience with modalities beyond traditional small molecules is beneficial, particularly including small molecule payloads.

#EligibleforERP

Required Skills:

Cancer Research, Drug Development, External Collaboration, High Performance Team Building, Immunotherapy, IND Submission, Innovation, Investigational New Drug (IND), Motivation Management, Multidisciplinary Collaboration, Oncology, People Leadership, Program Leadership, Project Leadership, Small Molecules, Strategic Management, Strategic Planning

Preferred Skills:

Current Employees apply

Current Contingent Workers apply

The salary range for this role is

$194,100.00 - $305,600.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits.  Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at .

You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully 
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

n/a

Job Posting End Date:

08/21/2026

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

About Merck & Co, Inc

Schering-Plough Corporation is a major U.S.-based manufacturer of pharmaceuticals. It operates in three segments: Prescription Pharmaceuticals, Animal Health, and Consumer Health Care. Schering-Plough develops products targeting on allergy, cancer, hepatitis, cardiovascular, central nervous system, respiratory system, and more.  It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. Schering-Plough manufactured several pharmaceutical drugs, the most well-known of which were the allergy drugs Claritin and Clarinex, an anti-cholesterol drug Vytorin, and a brain tumor drug Temodar. It also developed drugs targeting on central nervous system and the respiratory system. Schering Plough also owned and operated the major foot care brand name Dr. Scholl's and the skin care line Coppertone. These also became a part of the new company. Schering-Plough was a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA), a membership which is also maintained by the new Merck.

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We understand that our employees are our greatest asset, which is why we offer competitive benefits designed to support the health and well-being of you and your family. From comprehensive health care coverage and retirement plans to flexible working conditions and wellness programs, our benefits package is designed to meet the diverse needs of our team members.

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Learn more about Merck & Co, Inc
Size
68,000 employees
Market Cap
$282.6 billion
Industry
Net Income
$7 billion
Founded
1668
5 Year Trend
+4.1%
Revenue
$47.9 billion
NASDAQ

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