Career CategoryScientific
Job DescriptionScientist / Senior Scientist, Structural BiologyWhat you will doLet's do this. Let's change the world. In this vital role you will help discovery teams tackle challenging mechanistic questions by developing practical structural biology strategies, enabling high-quality structural analysis, and delivering insights that support therapeutic program decisions. This position offers a unique opportunity to combine hands-on structural biology with technology innovation in support of biologics and small-molecule drug discovery across multiple therapeutic areas.
Key Responsibilities
- Partner with discovery teams to evaluate samples, define structural biology strategies, and develop fit-for-purpose experimental plans.
- Perform and guide cryo-sample preparation, grid optimization, screening, data collection, image processing, model building, refinement, and structural interpretation.
- Deliver high-quality structural insights that inform mechanism of action, molecular design, and therapeutic decision-making.
- Develop scalable, reproducible CryoEM workflows that improve throughput, robustness, and data quality.
- Collaborate across Structural Biology, Protein Sciences, Therapeutic Discovery, Protein Engineering, Computational Biology, Medicinal Chemistry, Automation, Molecular Characterization, and therapeutic area teams.
- Coordinate activities across internal facilities, external collaborators, and instrument vendors to maximize platform performance.
- Evaluate and implement emerging technologies-including automation and AI-enabled tools-to improve data collection, analysis, and workflow efficiency.
- Apply complementary structural biology approaches, including X-ray crystallography, MicroED, electron tomography, and integrative structural biology, where appropriate to address scientific questions.
- Support and/or lead CryoEM platform activities at the South San Francisco site, including operation of the 200 kV Glacios 2 and user support for the 300 kV Titan Krios.
- Contribute to scientific innovation through technology development, publications, presentations, and knowledge sharing.
What we expect of youWe are all different, yet we all use our unique contributions to serve patients. The Scientist we seek is a researcher with these qualifications.
Basic Qualifications:Doctorate degree PhD in Structural Biology, Biochemistry, Biophysics, or a related field.
OR
PharmD
OR MD [and relevant post-doc where applicable]
OR
Master's degree and 3 years of Structural Biology experience
OR
Bachelor's degree and 5 years of Structural Biology experience
Preferred Qualifications:- Experience with X-ray crystallography, MicroED, electron tomography, or integrative structural biology.
- Experience supporting structure-based drug discovery in an industry setting.
- Experience studying membrane proteins, antibodies, multispecifics, GPCRs, or other challenging therapeutic targets.
- Experience developing new methodologies that improve throughput, reproducibility, or success rates.
- Familiarity with automated data collection software such as EPU.
- Experience mentoring scientists or training CryoEM users.
- Record of scientific publications, presentations, or technology innovation.
- Passion for collaborative science and continuous improvement.
- Experience scripting/coding with Python and/or other programming languages is a plus.
- Experience operating Glacios, Titan Krios, or equivalent high-end CryoEM instrumentation is a plus.
What you can expect from usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
Apply now and make a lasting impact with the Amgen team.careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadlineAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
SponsorshipSponsorship for this role is not guaranteed.
