PhD in Cell Biology, Molecular Biology, or related field; or MS with 5+ years or BS with 7+ years of relevant experience
Hands-on experience with LNP delivery and culturing primary cells (T-cells, hepatocytes) and/or cancer cell lines
Working knowledge of gene editing technologies (CRISPR, recombinases, base editors)
Experience with flow cytometry and laboratory automation for cell-based screening
Proficiency in nucleic acid QC methods (TapeStation, Qubit, NanoDrop, qPCR)
Track record of generating reproducible data and performing quantitative analysis
Strong communication skills for presenting complex information to diverse audiences
Responsibilities
Design and execute in vitro functional assays for candidate selection and preclinical development
Develop and optimize molecular and cytogenetic assays to measure genome editor activity and specificity
Support genome editor engineering by running high-throughput screens in relevant cell lines
Troubleshoot experiments, analyze data, and translate results into actionable insights
Maintain detailed laboratory notebooks and communicate findings to the scientific team
Collaborate across R&D to advance optimized candidates into translational and preclinical development
Benefits
Collaborative work environment with a team-first attitude
Opportunity to drive innovation in next-generation gene editing therapies
Engagement in diverse R&D projects across multiple disciplines
Access to cutting-edge technologies and methodologies in genome editing
Professional development opportunities in a rapidly evolving field
Full Job Description
About the Role:
Stylus Medicine is seeking a Scientist to join our Genome Sciences & Engineering team to drive innovation in next-generation gene editing therapies. In this role, the Scientist will drive the in vitro functional assessment of the company's lead genome editors to support the advancement of the company's lead programs through translational and preclinical development. This individual will play a key role in discovery and engineering efforts, advancing LSR-based genome editing platforms and collaborating across diverse R&D teams.
Key Responsibilities & Accountabilities:
Design and execute in vitro functional assays that support candidate selection and preclinical development of lead genome editors,advancing platform and program objectives
Develop and optimize molecular (ddPCR, qPCR) and cytogenetic (KromaTiD, optical genome mapping) assays to measure genome editor activity, specificity, transgene copy number, TCR repertoire, and biodistribution
Support genome editor engineering campaigns by running high-throughput screens in relevant cell lines, including primary human T-cells, and delivering timely, decision-quality data to guide candidate selection
Troubleshoot experiments, analyze data, and translate results into actionable scientific insights
Maintain detailed laboratory notebooks and clearly communicate data and findings to the broader scientific team
Partner across R&D to advance optimized candidates into translational and preclinical development
Qualifications & Skills:
PhD in Cell Biology, Molecular Biology, or a related field; or MS with 5+ years or BS with 7+ years of relevant experience
Hands-on experience with LNP delivery and expertise culturing primary cells (including, but not limited to T-cells and hepatocytes) and/or cancer cell lines
Working knowledge of gene editing technologies (CRISPR nucleases, recombinases, base editors, or transcriptional effectors)
Experience with flow cytometry and laboratory automation platforms for cell-based screening workflows
Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR
Track record of independently generating reproducible data and performing rigorous quantitative analysis
Strong written and verbal communication skills, with the ability to present complex technical information to both specialist and non-specialist audiences
Exceptional organizational skills, comfortable managing complex datasets and overlapping projects
Strategic thinker who plans and prioritizes for scientific impact
Clear, approachable communicator who makes complex concepts accessible across disciplines
Collaborative mindset with a team-first attitude
Decisive problem-solver who thrives amid scientific uncertainty
