M.S./M.A. in biochemistry or relevant biological science with 5+ years of experience, or B.S./B.A. with 8+ years of experience.
Strong background in assay development and optimization in mammalian cell culture.
Technical expertise in cell-based bioassays, SDS-PAGE/immunoblotting, and ELISA/multiplex assays.
Extensive experience in molecular biology, including molecular cloning and RNAseq.
Experience with oligonucleotide quantification and pharmacodynamic biomarker identification preferred.
Responsibilities
Design and execute assays for quantifying therapeutic oligonucleotides and assessing target mRNA and protein knockdown.
Develop and standardize cell-based assays using molecular cloning and stable cell line generation.
Conduct independent analysis and interpretation of experimental data.
Document experiments meticulously and present results to the team.
Collaborate effectively within a matrixed team environment.
Benefits
Opportunity to contribute to cutting-edge RNAi-based therapeutics development.
Collaborative work environment with a focus on innovation.
Professional growth and development opportunities.
Access to advanced technologies and methodologies in molecular biology.
Full Job Description
Position Summary:
Atalanta is seeking a highly motivated individual to join our In Vitro Biology team to contribute to the preclinical development of RNAi-based therapeutics. The selected individual is expected to design and execute assays for the quantification of therapeutic oligonucleotides, to assess the knockdown of target mRNAs and proteins and to assess additional molecular biomarkers of therapeutic efficacy. • The design and implementation of rigorous assays for the quantitation of oligonucleotides, mRNAs and proteins from cells and tissues. • Developing and standardizing cell-based assays, using skills in molecular cloning, stable cell line generation, cell culture and expression analysis • Independent analysis and interpretation of data, careful documentation of experiments and presentation of results within the company
Essential Functions: • A strong background in assay development, optimization and validation in mammalian cell culture • Technical expertise in cell-based bioassays, SDS-PAGE/immunoblotting and ELISA/multiplex assays • Extensive experience in molecular biology, including molecular cloning, creation of stable cell lines for target evaluation, mRNA expression analysis, RNAseq and DNA sequence analysis tools • Experience with oligonucleotide quantification, pharmacodynamic biomarker identification, and neurobiology are preferred • Ability to work and think independently while contributing as a part of a highly matrixed team • Excellent communication skills including interpersonal communication, presentations to groups, written reports and detailed record keeping
Education • M.S./M.A. in biochemistry or relevant biological science with an additional 5+ years of experience, or • B.S./B.A. in a relevant biological science with an additional 8+ years of experience
Please submit your CV and cover letter to [email protected] reference job code SRA-KS
