Scientist, Cell Culture Process Development

We are seeking a Scientist to join our Cell Culture Process Development team within Biologics CMC in West Chester, PA. This is a hands-on, lab-based role ideal for a motivated scientist with a strong foundation in mammalian cell culture and a passion for innovation in complex biologics production. You will design and execute mammalian cell culture studies, translate data into process decisions, and help develop robust, scalable, and manufacturable cell culture processes for therapeutic proteins. The role spans early and late-stage development to support clinical and commercial manufacturing. The role offers meaningful ownership, and exposure to high-throughput bioreactor systems, pilot-scale operations, modern automation and data modeling tools, and collaboration across the biologics CMC organization. How You'll Spend Your Day • Design, execute, analyze, and document mammalian cell culture experiments with strong scientific rationale. • Develop and optimize cell culture and harvest process, media, and feeding strategies to improve process performance, robustness, productivity, and product quality. • Operate and troubleshoot mammalian cell culture systems across scales, including shake flasks, high-throughput or automated bioreactors, bench-scale bioreactors, and pilot-scale equipment. • Apply scale-up and scale-down principles to establish representative models and translate process knowledge toward clinical and commercial manufacturing. • Use DOEs, multivariate analysis, data modeling and digital tools to identify critical process relationships and enable data-driven decisions. • Integrate cell culture performance with analytical and product quality data to build mechanistic process understanding and inform control strategies. • Contribute to process characterization, new technology evaluations, facility-fit assessments, as appropriate for program stage. • Partner with Cell Line Development, Purification Process Development, Analytical Development, Manufacturing, Quality, Regulatory, and external collaborators to deliver integrated CMC outcomes. • Communicate conclusions and recommendations through technical reports, protocols, presentations, and regulatory submission content, including IND and BLA sections. • Promote safe laboratory practices, data integrity, high-quality documentation, continuous improvement, and an inclusive team environment. What Success Looks Like • You deliver well-designed, reproducible studies that answer important development questions and support timely program decisions. • You translate experimental results into clear recommendations for robust, scalable, and manufacturable cell culture processes. • You build trusted partnerships across functions, communicate risks early, and contribute to a culture of scientific rigor, ownership, and continuous learning. Your Skills and Experience • M.S. or B.S. in Chemical/Biochemical Engineering, Cell Biology, or related field with 6+ years or 8+ years of experience respectively. • Strong hands-on experience in mammalian cell culture, media/feed development, and bioreactor operations. • Hands-on experience with mammalian suspension cell culture and bioreactor-based process development for recombinant proteins or other biologics. • Demonstrated ability to independently plan experiments, analyze complex data, troubleshoot technical challenges, and draw clear, defensible conclusions. • Working knowledge of cell culture process fundamentals, including growth, metabolism, productivity, product quality, media and feed effects, and scale-dependent process behavior. • Clear written and verbal communication skills and the ability to collaborate effectively in a matrixed, multidisciplinary environment. Also Good to Have • Experience with CHO cell culture, fed-batch processes, automated or high-throughput bioreactor platforms, and continuous centrifugation. • Experience with process scale-up or scale-down, process characterization, technology transfer, pilot-scale production, or manufacturing support. • Proficiency with statistical applications such as JMP and or SIMCA and practical use of DoE or multivariate analysis. • Experience connecting process data with product quality attributes and using digitalization, automation, data visualization, modeling, PAT, or omics approaches to strengthen process understanding. • Familiarity with cGMP principles, data integrity expectations, and technical or regulatory documentation for biologics development. How We'll Take Care of You We offer a competitive benefits package, including: • Comprehensive Health Insurance: Medical, Dental, Vision, and Prescription coverage starting on the first day of employment, providing the employee enrolls. • Retirement Savings: 401(k) with employer match, up to 6% and an annual 3.75% Defined Contribution to the 401k plan. • Time Off: Paid Time Off including vacation, sick/safe time, caretaker time and holidays. • Life and Disability Protection: Company paid Life and Disability insurance. • Additional benefits include, but are not limited to, Employee Assistance Program, Employee Stock Purchase Plan, Tuition Assistance, Flexible Spending Accounts, Health Savings Account, Life Style Spending Account, Volunteer Time Off, Paid Parental Leave, if eligible , Family Building Benefits, Virtual Physical Therapy, Accident, Critical Illness and Hospital Indemnity Insurances, Identity Theft Protection, Legal Plan, Voluntary Life Insurance and Long Term Disability and more. The total compensation may also include restricted stock units and discretionary awards, depending on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. Make sure to apply through our internal career site on Twist-your one-stop shop for career development