Career CategoryScientific
Job DescriptionPrincipal Scientist - Cardiometabolic Diseases/Obesity ResearchWhat you will doLet's do this. Let's change the world. In this vital role you will provide scientific leadership for the discovery and preclinical development of next-generation therapeutics for obesity and related cardiometabolic diseases. You will lead the design and execution of translational pharmacology strategies to advance innovative therapeutic candidates from target validation through candidate selection.
As a Principal Scientist, you will drive scientific excellence across multiple discovery programs by integrating human biology, in vitro pharmacology, and in vivo efficacy studies to establish a robust pharmacological understanding and enable data-driven decision making. You will work closely with multidisciplinary teams spanning biology, protein engineering, pharmacokinetics, toxicology, biomarker sciences, computational biology, and clinical development.
Key Responsibilities- Provide scientific leadership for obesity drug discovery programs from target identification and validation through candidate selection.
- Develop and implement translational pharmacology strategies to evaluate novel therapeutic mechanisms and optimize candidate molecules.
- Design, oversee, and interpret in vitro and in vivo pharmacology studies, including efficacy, mechanism-of-action, PK/PD, and biomarker investigations.
- Lead cross-functional scientific discussions and influence program direction through rigorous data interpretation and critical thinking.
- Identify and implement innovative pharmacology approaches and emerging technologies to advance GPCR-targeted drug discovery.
- Mentor and develop scientists while fostering scientific excellence, innovation, and collaboration.
- Present scientific findings and recommendations to project teams, senior leadership, and external scientific audiences.
- Contribute to publications, presentations, and scientific strategy that strengthen Amgen's obesity research portfolio.
What we expect of youWe are all different, yet we all use our unique contributions to serve patients. The Principal Scientist we seek is an accomplished scientific leader with these qualifications.
Basic Qualifications:Doctorate degree PhD
OR
PharmD
OR
MD [and relevant post-doc where applicable] and 2 years of experience in pharmaceutical, biotechnology, or related drug discovery research
OR
Master's degree and 5 years of experience in pharmaceutical, biotechnology, or related drug discovery research
OR
Bachelor's degree and 7 years of experience in pharmaceutical, biotechnology, or related drug discovery research
Preferred Qualifications:- PhD in Pharmacology, Physiology, Endocrinology, Cell Biology, Molecular Biology, or a related scientific discipline with 5+ years of experience in pharmaceutical or biotechnology drug discovery.
- Extensive expertise in GPCR biology, pharmacology, and signaling, with a deep understanding of receptor pharmacology, signal transduction, and mechanism-of-action studies.
- Demonstrated experience developing, optimizing, and applying GPCR-based in vitro pharmacology assays, including functional signaling assays, ligand-binding assays, receptor internalization, -arrestin, cAMP, calcium mobilization, and pathway-selective (biased signaling) analyses.
- Strong expertise in pharmacological characterization of peptide, antibody, multispecific, or other biologic therapeutics.
- Experience designing and interpreting in vivo pharmacology studies to support target validation, mechanism-of-action, and candidate selection.
- Demonstrated ability to integrate in vitro pharmacology, in vivo efficacy, PK/PD, biomarker, and human biology data to guide scientific decisions and advance discovery programs.
- Proven scientific leadership with the ability to independently develop innovative scientific strategies, solve complex biological problems, and influence multidisciplinary project teams.
- Experience mentoring scientists and leading cross-functional collaborations in a fast-paced drug discovery environment.
- Excellent written and verbal communication skills with a strong track record of publications, presentations, and scientific contributions.
- Demonstrated creativity, scientific curiosity, and a passion for discovering transformative therapies for patients with obesity and related metabolic diseases.
What you can expect of usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
Apply now and make a lasting impact with the Amgen team.careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadlineAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
SponsorshipSponsorship for this role is not guaranteed.
