Position SummaryWe are seeking a Principal Research Scientist to lead our Molecular Pharmacology team and in vitro pharmacology strategy across Small Molecule, Large Molecule, and Parasitology discovery.
This role requires strong small-molecule drug discovery experience, deep cell-based and biochemical assay expertise, direct people leadership, and the ability to translate pharmacology data into lead optimization and candidate-selection decisions.
What You'll Do (Your Impact)- Lead and develop a team of scientists.
- Own in vitro pharmacology and assay strategy across discovery programs.
- Design and optimize cell-based and biochemical assays for potency, MOA, target engagement, and cellular response.
- Partner with medicinal chemistry and discovery teams to support SAR, lead optimization, and candidate progression.
- Provide scientific leadership across multiple programs and build new assay capabilities where needed.
- Ensure high-quality pharmacology data supports go/no-go and candidate-selection decisions.
What You Need to Succeed (minimum qualifications):- Ph.D. in a related scientific discipline with 12+ years of relevant industry experience, or M.S. with 15+ years.
- Strong experience in molecular/in vitro pharmacology and small-molecule drug discovery.
- Demonstrated ownership of assay strategy and development, not just assay execution.
- Experience supporting compound characterization, lead optimization, and progression decisions.
- Direct people-management experience, including coaching and developing scientists.
- Strong cross-functional scientific leadership within drug discovery.
What will give you a competitive edge (preferred qualifications):- Extensive medicinal chemistry partnership and SAR experience.
- Experience with biologics or other large-molecule modalities.
- Parasitology or parasite-host biology experience.
- Experience with automation, HTS, or building new assay platforms.
Additional Information:This role is based in Indianapolis and will work closely with cross-functional discovery teams across Elanco R&D.
Don't meet every single requirement? Studies have shown underrepresented groups are less likely to apply to jobs unless they meet every single qualification. At Elanco we are dedicated to building a diverse and inclusive work environment. If you think you might be a good fit for a role but don't necessarily meet every requirement, we encourage you to apply. You may be the right candidate for this role or other roles!
Elanco Benefits and Perks:We offer a comprehensive benefits package focusing on financial, physical, and mental well-being while encouraging our employees to pursue our purpose! Some highlights include:
- Multiple relocation packages
- Two weeklong shutdowns (mid-summer and year-end) in the US (in addition to PTO)
- 8-week parental leave
- 9 Employee Resource Groups
- Annual bonus offering
- Flexible work arrangements
- Up to 6% 401K matching
