Key Responsibilities- Lead translational biomarker strategy for IND-enabling and Phase 1/2 programs, translating preclinical hypotheses into clinical assay plans with a focus on target engagement and PD.
- Direct the design, development, qualification/validation, and implementation of assays that support clinical endpoints and mechanistic understanding, ensuring scientific rigor, feasibility, and regulatory alignment.
- Oversee assay-related activities conducted by CROs, including protocol review, data quality assessment, and troubleshooting.
- Author and review regulatory documents supporting clinical development.
Preferred Education & Experience (Qualifications)- PhD or MS in translational sciences, pharmacology biochemistry, bioanalytical science, or a related discipline.
- 8+ years of relevant industry or translational research experience.
- Hands-on experience developing or implementing biomarker strategy and assays supporting IND submission and Phase 1/2 programs.
- Working knowledge of bioanalytical principles, biomarker assay validation guidelines, and clinical sample workflows.
- Demonstrated ability to manage external partners and communicate effectively in cross-functional environments.
Nice-to-Haves- Experience working in a biotech or fast-paced clinical development environment.
- Enzymology experience, such as enzyme kinetics, mechanism-of-action characterization, or development of enzyme activity assays to measure target engagement and PD.
- Expertise with multiple assay formats (e.g., ligand-binding, molecular, cell-based, and enzymatic activity assays).
- Experience contributing to regulatory submissions involving nonclinical pharmacology, biomarker, or assay component.
- No matter your role at GondolaBio, successful team members are Patient Champions, who put patients first and uphold strict ethical standards.
- Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset.
- Truth Seekers, who are detailed, rational, and humble problem solvers.
- Individuals Who Inspire Excellence in themselves and those around them.
- High-quality executors, who execute against goals and milestones with quality, precision, and speed.
What We Offer- Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts.
- A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak.
- An unyielding commitment to always putting patients first.
- A decentralized model that enables our program teams to focus on advancing science and helping patients.
- A place where you own the vision - both for your program and your own career path.
- A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game.
- Access to learning and development resources to support career growth.
- Robust and market-competitive compensation & benefits package.
- Flexible PTO.
- Rapid career advancement for strong performers.
- Commitment to Diversity, Equity & Inclusion.
The base pay range for this position is $200,000 to $225,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered.
Employees of BridgeBio and all affiliated companies should work through their managers to inquire about and learn more about this role.
