Jobs in All Categories (22) Healthcare (2) Human Resources & Legal (1) Operations & General Management (1) Science & Education (18)
Responsible for discovery research focused in glial biology for neurodegenerative disorders and is expected to lead a team in Discovery Biology and make scientific laboratory based contributions to achieve research milestones.
Perform drug discovery research in collaboration with others. Support identification and validation of signaling pathways and targets.
Design novel fusion proteins, multispecific antibodies, and linker sequences that will be incorporated into candidate medicines.
Develop Denali's internal AAV vector platform and produce material for preclinical and research applications.
Serve as a functional leader for analytical and formulation development and developability assessments for therapeutic protein products.
Analyze, interpret, summarize and present PK and disposition data to internal project teams, senior management, and to global health authorities.
Evaluate and recommend Cell Line Development technologies and contract manufacturing organizations to ensure the successful development of lead biotherapeutics.
Analyze, interpret, summarize and present large molecule DMPK/BA data to internal project teams, senior management, and to global health authorities.
Develop and execute strategy to build capabilities, both internal and external, to support the development portfolio over time including novel modalities.
Design and implement biomarker assays including plate-based immunoassays, multiplex Luminex assays, flow cytometry, and immunohistochemistry.
Draft, file and prosecute patent applications with a primary focus on the protection of large molecule inventions and patent prosecution.
The candidate will drive efforts to identify and prioritize novel therapeutic targets and biomarkers of disease by combining and integrating human genetics and functional genomics data.
Support identification and validation of signaling pathways and targets in the areas of stress-granule biology and protein homeostasis using techniques like pooled CRISPR screening and small-molecule phenotypic screening.
Perform research and collaborate with colleagues across diverse functional areas to achieve research goals.
Responsible for the design, execution, analysis, interpretation and presentation of clinical and translational studies.
The Medical Director will be responsible for design, implementation, monitoring, analysis, and reporting of clinical trials, specifically in our Alzheimer's Disease programs, and will provide strategic leadership for these development programs.
Lead activities associated with the evaluation, initiation and management of clinical studies to ensure compliance with SOPs, FDA regulations and ICH/GCP guidelines.
Serve as a data management expert and be the CDM lead for assigned clinical studies on multidisciplinary project teams.
Develop strategy and manage integrated project plans, timeline, risks and costs associated with candidate progression through research, pre-clinical and clinical development.
Work hand-in-hand with the Project Leader to develop and execute program strategies and lead project teams to advance programs from discovery through clinical development.
Negotiate and manage a variety of contracts, including confidentiality, consulting and service agreements.