The Opportunity

This is one of the most consequential science leadership roles in Amazon Business. As Applied Science Manager, you will directly influence over $40B in annual revenue by owning the science strategy that powers how we acquire, engage, monetize, and retain millions of business customers worldwide. Your models won't sit in notebooks. They will run in production, shaping real-time decisions across the full customer lifecycle for one of Amazon's fastest-growing businesses.

You will operate at the intersection of Business Prime, Marketing Science, and Customer Acquisition three of the highest-visibility, highest-impact charters in the organization. Your work will be presented to VPs and SVPs, inform multi-billion-dollar investment decisions, and fundamentally reshape how Amazon Business goes to market. This is not an incremental optimization role. This is a build-the-future role where your science roadmap becomes the business strategy.

What You'll Own

Team Leadership & Talent Development: Build and lead a world-class team of applied scientists and research scientists. Set the technical vision, define the multi-year science roadmap, and create an environment where scientists ship models that move the needle on $40B+ in revenue. You will be the bar-raiser who attracts top talent and develops the next generation of science leaders at Amazon.

Customer Lifecycle Intelligence ($40B+ Revenue Impact): Own the predictive modeling stack that powers customer identification, targeting, spend behavior forecasting, churn propensity, and declining engagement detection across every Business Prime segment. Your models will determine which customers we invest in, how we invest, and when directly impacting billions in customer lifetime value.

Marketing Science & Measurement (Cross-Functional, Multi-Billion Dollar Allocation): Build the causal inference and attribution frameworks that determine how Amazon Business allocates hundreds of millions in marketing investment across paid, owned, and earned channels globally. You will be the single point of science truth for incrementality measurement, marketing mix modeling, and ROI optimization partnering with Marketing, Finance, CPS, and international teams to ensure every dollar drives maximum impact.

Customer Acquisition Engine: Lead the science that accelerates new Business Prime member acquisition at scale. Build propensity models, audience optimization systems, and channel effectiveness frameworks that feed directly into acquisition engines serving 10+ global markets. Your work will be the difference between linear growth and exponential growth.

Benefits Adoption & the "Aha Moment": Build behavioral segmentation and recommendation systems that identify, for each customer vertical and organizational profile, the exact moment and feature combination that converts a trialist into a loyalist. This is the science of delight at scale.

Trust & Safety at Scale: Develop fraud detection models, abuse identification systems, and eligibility classifiers that protect the integrity of the Business Prime ecosystem safeguarding billions in revenue from bad actors.

Experimentation & Causal Inference (Organization-Wide): Establish the experimentation frameworks and causal inference methodologies used across the entire Amazon Business organization. Design experiments that measure incremental impact of product launches, pricing changes, and marketing interventions creating the scientific foundation for how leadership makes high-stakes decisions.

Why This Role Is Different

This is not a role where you optimize a feature in isolation. You will sit at the center of a complex, cross-functional operating model partnering daily with 7+ senior leaders (including Directors and VPs) across Business Prime, CPS Sales, Central Marketing, SSR, GTMO, Finance, and International teams. Your science will be the connective tissue that aligns these organizations around a shared, data-driven growth strategy.

You will have direct senior leadership visibility - presenting findings, recommendations, and roadmaps to VP audiences regularly. The insights your team generates will shape OP1/OP2 planning, Board-level narratives, and multi-year investment theses.

What We're Looking For

The successful Applied Science Manager will have an bias for action in a startup environment, with people leadership skills, a proven ability to build and manage high-performing science teams, define and prioritize research agendas that map to business outcomes, and build methodology and tools that are statistically grounded. You influence product and business strategy through science translating complex analytical findings into crisp, actionable recommendations that senior leaders act on immediately.

We are seeking someone who thrives in a fast-paced, high-energy, and fun work environment where we deliver value incrementally and frequently. You are a highly technical leader who knows your subject matter deeply, can elevate the technical bar of your team, and is energized by ambiguity and new problem spaces. You know how to deliver results and show a desire to develop yourself, your colleagues, and your career.

BASIC QUALIFICATIONS

- 3+ years of scientists or machine learning engineers management experience

- Knowledge of ML, NLP, Information Retrieval and Analytics

PREFERRED QUALIFICATIONS

- Experience building machine learning models or developing algorithms for business application

- Experience building complex software systems, especially involving deep learning, machine learning and computer vision, that have been successfully delivered to customers

The base salary range for this position is listed below. Your Amazon package will include sign-on payments and restricted stock units (RSUs). Final compensation will be determined based on factors including experience, qualifications, and location. Amazon also offers comprehensive benefits including health insurance (medical, dental, vision, prescription, Basic Life & AD&D insurance and option for Supplemental life plans, EAP, Mental Health Support, Medical Advice Line, Flexible Spending Accounts, Adoption and Surrogacy Reimbursement coverage), 401(k) matching, paid time off, and parental leave. Learn more about our benefits at https://amazon.jobs/en/benefits.

USA, WA, Seattle - 183,800.00 - 248,700.00 USD annually