Let’s do this. Let’s change the world. Amgen is a leader in the discovery and development of innovative cancer therapeutics. The Oncology Research team seeks a Director of Research to develop and lead a portfolio of antibody-based therapeutics for solid tumors. In this role, you will work cross-functionally to implement and advance next-generation approaches for cancer therapeutics.

The ideal candidate will have direct experience leading oncology T-cell engager programs from discovery to development candidate nomination, with experience using translational biology approaches to inform clinical development. A deep and broad understanding of cancer cell biology, including human genetics, cell growth signaling pathways, mechanisms of response and resistance, and translational pharmacology will be essential. You will be responsible to lead project teams and external collaborations, as well as to inspire and develop a creative, dedicated research team. You will be an exceptional scientific leader who can translate strategy to execution in a fast-paced, changing matrixed environment. This role has the potential for high visibility within Amgen and externally.

Key Responsibilities:

• Lead preclinical research for T cell engager focused on identification of novel target opportunities, prioritization of discovery investments, and implementation of next-generation target discovery approaches.
• Build and lead a portfolio of innovative research programs focused on bispecific antibodies.
• Lead a team of project leaders and lab-based scientists to; create an inclusive high-performing environment that enables new target discovery, rigorous science and efficient execution.
•  Lead cross-functional teams and engage key internal partners to integrate tumor biology, target validation, translational research, therapeutic modality considerations, and portfolio strategy.
•  Establish productive external scientific collaborations and contribute to evaluation of external opportunities, including business development diligence.
•  Partner effectively with peers across research and development to advance new science and integrate technology with tumor cell biology, including application of AI/ML approaches to target and biology evaluation.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications:

Doctorate degree in Cancer Biology, Cell Biology, Genetics, or related field [and relevant post-doc where applicable] and 4 years of directly related experience

OR

Master’s degree in Cancer Biology, Cell Biology, Genetics, or related field [and relevant post-doc where applicable] and 8 years of directly related experience

OR

Bachelor’s degree in Cancer Biology, Cell Biology, Genetics, or related field [and relevant post-doc where applicable] and 10 years of directly related experience

In addition to meeting at least one of the above requirements, you must have at least 4 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources.  Your managerial experience may run concurrently with the required technical experience referenced above

Preferred Qualifications:

• Doctoral degree in a Cancer Biology, Cell Biology or related field with at least 12 years industry experience following completion of postdoctoral training.
• Demonstrated experience leading drug discovery and development programs through IND/CTA-enabling activities, with strong experience in large-molecule therapeutics and understanding of the preclinical data sets required for development candidate nomination.
• Deep understanding of oncology and tumor biology; expertise in NSCLC or lung cancer biology is strongly preferred.
• Knowledge of antibody engineering approaches, with direct experience designing and evaluating modalities including T-cell engagers and antibody-drug conjugates.
• Established record of building, mentoring, and leading high-performing research teams.
• Exceptional written and verbal communication skills, with the ability to synthesize complex data into clear strategic recommendations.
• Demonstrated scientific impact through publications, patents, invited presentations, or other external recognition.
• Demonstrated ability to use AI/ML to accelerate research and translational biology.

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship for this role is not guaranteed.

Salary Range