DescriptionHeadquarters Location: Emeryville, CA
Candidate Location: Hybrid
Travel Required: 10%
Reports To: Vice President, Clinical Operations
Department: Clinical Operations
Position Type: Full-time, Exempt
Who You Are and What You'll Do:You are passionate about life sciences and making a difference to cancer patients, their families, and healthcare providers. You will lead clinical operations for assigned oncology studies, translating development and functional strategies into executable study plans, clear team priorities, reliable forecasts, and quality delivery. Reporting to the Vice President, Clinical Operations, you will manage and develop employees, oversee external partners, and collaborate across Clinical Development, Biometrics, Regulatory, Quality, CMC, Safety, and other functions. Near-term priorities include strengthening operational readiness for expanding and later-phase studies, advancing study start-up and enrollment execution, and improving scalable processes, metrics, and vendor oversight.
Job Responsibilities: - Lead end-to-end clinical operations for assigned global studies, including operational planning, start-up, site activation, enrollment, study conduct, closeout, and inspection readiness.
- Translate program and protocol strategy into integrated operational plans, timelines, budgets, resourcing models, risk assessments, quality measures, and decision points.
- Independently manage approved study and team resources; monitor forecasts and actuals, identify variances, and recommend actions that protect quality, timelines, and responsible use of resources.
- Select, contract with, and oversee CROs and other vendors. Establish performance expectations, governance, metrics, escalation pathways, and corrective actions.
- Partner with cross-functional stakeholders to ensure operational feasibility, timely study-document finalization, site selection and activation, data review, clinical-sample flow, drug-supply continuity, and regulatory deliverables.
- Use operational data and leading indicators to assess enrollment, monitoring, data entry and verification, queries, action items, TMF completeness, sample reconciliation, and vendor performance; drive timely risk mitigation and escalation.
- Ensure studies are conducted in accordance with applicable protocols, GCP, regulatory requirements, quality standards, contracts, and internal procedures. Support audits, inspections, and issue remediation.
- Lead development and continuous improvement of clinical-operations infrastructure, including SOPs, work instructions, tools, templates, dashboards, and scalable ways of working for later-phase readiness.
- Participate in functional and cross-functional strategy, governance, and portfolio discussions. Present concise operational recommendations, tradeoffs, risks, and decisions to senior stakeholders.
- Manage, coach, and develop employees. Set clear goals and decision rights, provide timely feedback, support development plans, recognize performance, and build an inclusive, accountable, high-performing team.
- Delegate appropriately while maintaining oversight of critical decisions, commitments, quality, and delivery. Foster collaboration and prompt resolution of conflicts and operational issues.
Minimum Qualifications: - Bachelor's degree in a life-sciences, health-sciences, nursing, pharmacy, or related field, or an equivalent combination of relevant education and experience.
- 8 years of progressive clinical-operations experience in biotechnology or pharmaceutical drug development with at least 5 years of leadership of complex, multi-site clinical trials and oversight of CROs and vendors.
Preferred Qualifications: - Demonstrated people-management experience, including setting expectations, coaching, performance feedback, development planning, and delegation.
- Working knowledge of Good Clinical Practice and applicable clinical-trial regulations, with experience applying quality and risk-based approaches to study execution.
- Demonstrated ability to manage study plans, budgets, forecasts, timelines, operational metrics, risks, and cross-functional decisions with a high degree of independence.
- Experience in oncology clinical development and in studies progressing from early development toward Phase 2 or Phase 3 readiness.
- Experience with global study start-up, site activation and enrollment strategy, TMF oversight, clinical-sample operations, and clinical drug-supply coordination.
- Experience leading inspection-readiness activities, process improvement, SOP development, and implementation of clinical-operations systems or analytics tools.
- Experience communicating clinical-operations strategy, risks, and recommendations to senior governance forums.
How You Will Work:- Demonstrates collaboration and teamwork. Works well with others and understands that collaboration leads to better results.
- Possesses strong communication skills. Communicates clearly, concisely, and professionally. Listens actively to build understanding.
- Exhibits strong interpersonal skills and self-awareness. Builds and cultivates strong and enduring relationships with others. Acts with humility and understands own strengths and weaknesses.
- Shows continuous improvement and a commitment to self-management and development. Operates with a continuous improvement mindset and continuously seeks to expand own knowledge and capabilities.
- Demonstrates a patient focus. Puts the patient first in actions and decisions taken.
- Contributes to strategy and innovation. Contributes to or leads elevating and actionable strategies. Ideates and creates unique opportunities to advance the organization.
- Demonstrates leadership and a commitment to organizational values. Takes ownership and has a strong sense of personal accountability. Consistently achieves or exceeds goals and expectations. Puts significant emphasis on living / upholding company values.
- Demonstrates ability and commitment to building effective teams. Attracts, develops, and retains diverse top talent. Aligns, mobilizes, and engages others to achieve and sustain peak performance.
- Has a track record of driving vision and purpose in teams.
Compensation, Benefits, and So Much More - The expected salary range for this role based on the primary location for this position in California is $225,000 - $245,000 per year. Offer amounts are determined by factors such as experience, qualifications, geographic location, and other job-related factors permitted by law.
- A great environment where we work collaboratively, leverage each other's strengths, and work toward a shared vision with our common goals of doing the best thing for patients.
- A robust and enduring approach to your development and career growth fueled by a strong learning curriculum and career guidance that helps you understand how you can grow your career at CytomX.
- A robust and highly competitive total rewards program that helps you achieve your compensation goals while supporting a great work / life balance.
Conditions of Employment - Background investigations are required for all positions at CytomX, consistent with applicable law.
