Eli Lilly

Associate Scientist - Oligo Synthesis

Eli Lilly • $66K — $171K *
Indianapolis, IN 46227In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
Today
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Job Overview by Ladders

Qualifications

  • BS/MS in Organic Chemistry, Chemistry, Biochemistry, or related field with 2+ years industry experience.
  • Authorization to work in the U.S. on a full-time basis without sponsorship.

Responsibilities

  • Synthesize therapeutic oligonucleotides using automated solid-phase synthesizers at varying scales.
  • Independently solve synthetic challenges to improve laboratory workflows.
  • Collaborate with discovery chemistry teams for novel molecule scale-up requirements.
  • Engage with the analytical team for molecule analysis and characterization.
  • Oversee team scientists and prioritize their work effectively.
  • Support the development of lead therapeutic candidates in collaboration with CMC and innovation teams.
  • Maintain lab equipment and manage inventory for efficient operations.
  • Implement new technologies to accelerate innovation in genetic medicines.

Benefits

  • Eligibility for a company-sponsored 401(k) and pension plan.
  • Vacation benefits and various leave of absence options.
  • Medical, dental, vision, and prescription drug coverage.
  • Flexible spending accounts for healthcare and dependent care.
  • Life insurance and other death benefits.
  • Employee wellness programs and activities.
Full Job Description
The Lilly Genetic Medicines Team is looking for a collaborative, creative, and energetic problem solver to join a multidisciplinary team at the front edge of innovation. You will join our fast-paced, interdisciplinary team as we use novel RNA/oligonucleotide based therapeutic modalities to enhance the Lilly portfolio. The successful applicant will use their knowledge and technical expertise to accelerate the core capabilities and development of internal RNAi-based clinical candidates.

Key Responsibilities include:
  • Synthesize therapeutic oligonucleotides (ASO, siRNA, and others) from 75-6000 umol scales using automated solid-phase synthesizers.
  • Independently problem-solve in the laboratory setting to overcome synthetic challenges and continuously improve existing workflows.
  • Collaborate with members of the LGM discovery chemistry teams to understand and validate requirements for synthesis scaleup of novel molecules
  • Collaborate with our analytical team for the proper analysis and characterization of processed molecules
  • Oversee and prioritize the work of scientists supporting the team
  • Actively support our efforts toward the discovery and development of lead therapeutic candidates and collaborate with CMC and development teams to drive high-speed innovation towards the clinic
  • Maintain laboratory equipment and manage laboratory inventory/consumables for efficient lab operations
  • Support the implementation of new technologies and workflows that accelerate innovation for LGM


Basic Qualifications:
  • BS/MS in Organic Chemistry, Chemistry, Biochemistry, or a related scientific discipline with 2+ years of relevant industry experience.
  • Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.


Additional Skills/Preferences:
  • Strong laboratory skills and experience with oligonucleotide instrumentation including but not limited to AKTA Oligosynth, AKTA OP100, Mermade 12, AKTApure, and TFF (tangential flow filtration) systems.
  • Strong laboratory skills and experience with analytical instrumentation such as Agilent LC-MS and UPLC, Orbitrap MX, etc.
  • Demonstrated ability and experience with successful translation of proof-of-concept chemistry to large scale solid-phase instrumentation
  • Strong hands-on experience with phosphoramidite and nucleoside chemistry, particularly in the context of oligonucleotide synthesis with an understanding of impurity profiles in these reagents and their impact on oligonucleotide quality
  • Experience with analytical techniques for small molecule characterization such as HPLC, LC-MS, NMR, and UV spectroscopy.
  • Ability to enhance synthesis efficiency with optimized methods, instrument awareness, high attention to detail, and ongoing team collaboration.
  • Ability to troubleshoot common synthesis failures due to solubility, moisture sensitivity, or reagent degradation and implement the appropriate mitigation.
  • Ability to identify and implement strategies that streamline operations, reduce waste, and enhance overall efficiency.
  • Confident, execution-focused teammate who thrives in a fast-paced, collaborative lab environment, managing multiple concurrent syntheses and shifting priorities.
  • Strong communication and organizational skills, with high attention to detail in record keeping, independent data analysis, documentation, and process control to ensure accurate, compliant reporting
  • Intellectually curious, with a genuine eagerness to learn new instrumentation, techniques, and chemistries for novel platforms and modalities

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$66,000 - $171,600

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

About Eli Lilly

ICOS Corporation is a biotechnology company that engages in the discovery, development, and commercialization of therapeutic products. It is engaged in the commercialization of treatments for unmet medical conditions, such as benign prostatic hyperplasia, hypertension, pulmonary arterial hypertension, cancer, and inflammatory diseases. It is the developer of a treatment known as Cialis (tadalafil), a product for the treatment of erectile dysfunction through its joint venture with Eli Lilly and Company in North America and Europe. It is also engaged in contract manufacturing services for third parties. It is in a strategic alliance with Solvay Pharmaceuticals, Inc. ICOS Corporation was established in 1989, based in Bothell, Washington. It is currently operated by Eli Lilly and Company.

Eli Lilly Careers

Joining Eli Lilly offers an unparalleled opportunity to become part of a leading global team dedicated to creating a healthier future. As a company revered for its commitment to innovation and leadership in the pharmaceutical industry, Eli Lilly is where your professional journey can flourish. Work You’ll Do At Eli Lilly, we are passionate about transforming patient care and advancing medical innovation. Our team at Eli Lilly is at the forefront of developing groundbreaking solutions in healthcare. By joining us, you will collaborate with some of the brightest minds in the industry, using cutting-edge technology to make real-world impacts. Lead with Innovation and Leadership Eli Lilly stands out in the marketplace by integrating deep industry expertise with robust research and development efforts. We are looking for professionals who are eager to drive change and lead the way in developing therapeutic breakthroughs. Explore Job Opportunities and Growth Eli Lilly offers a variety of career paths, including full-time positions and internships, across multiple functions such as research, marketing, IT, and sales. Whether you are a seasoned professional or a recent graduate, Eli Lilly provides an environment that promotes career growth and learning opportunities. Our commitment to diversity and leadership training ensures that every employee can achieve their potential. Be Part of Our Team Our team at Eli Lilly is committed to excellence and driven by a mission to improve lives. Employees enjoy a supportive culture that values collaboration, creativity, and diversity. We believe that a diverse workforce fosters innovation and helps us better connect with the communities we serve. Benefits and Culture Eli Lilly is dedicated to supporting our employees, offering competitive benefits, wellness programs, and comprehensive health care. Our culture is built on a foundation of respect, integrity, and quality, making Eli Lilly not just a great place to work, but a community to grow with. Networking and Professional Development Eli Lilly encourages continuous professional development and networking. With access to various training programs and mentorship opportunities, employees can enhance their skills and advance their careers. Our leadership is committed to nurturing talent through effective training and development strategies. Join Our Team Discover the exciting job opportunities at Eli Lilly by exploring open positions that match your skills and interests. We are continuously hiring and looking for individuals who are passionate, innovative, and ready to contribute to our mission of making life better for people around the globe. Stay Connected Keep up to date with the latest at Eli Lilly by following our careers blog. Gain insights from industry leaders and get tips on everything from crafting the perfect resume to preparing for your interview. Eli Lilly is not just a company—it's a place where you can make a difference. Explore the positions available and find out how your talents can help change the world. SEARCH ELI LILLY JOBS Stay ahead in your career with Eli Lilly, where innovation, leadership, and a commitment to diversity and growth lead the way to future advancements.
Learn more about Eli Lilly
Size
35,000 employees
Market Cap
$344.2 billion
Industry
Pharmaceuticals & Biotech
Net Income
$6.1 billion
Founded
1876
5 Year Trend
+5.9%
Revenue
$24.5 billion
NASDAQ
LLY
* Ladders Estimates

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