Our ADME team is seeking a scientist with an interest in the discovery and clinical development of genetic medicines, including gene editing, gene therapy, siRNAs, ASOs, and other emerging modalities. We develop transformative therapeutics that address the underlying causes of disease across a wide range of therapeutic areas. We welcome applicants with strong problem-solving skills and innovative thinking to join our growing Boston campus team.
Lilly's ADME team collaborates with biologists, chemists, engineers, and other R&D functions across all stages of discovery and development, sharing learning and responsibility for advancing next-generation genetic therapies. We foster professional growth and welcome motivated, collaborative scientists who want to help improve patient outcomes globally.
A high-quality candidate will demonstrate the following:- High learning agility and the ability to articulate and efficiently test ADME and PK/PD hypotheses for complex novel molecules
- Strong working knowledge in fundamental pharmaceutics, pharmacokinetics/pharmacodynamics, and ADME principles - especially as they relate to genetic medicine therapeutic modalities
- Ability to interrogate diverse data (e.g., in silico, in vitro, in vivo) to derive mechanistic understanding of drug action and ADME/DMPK characteristics
- Understanding of pharmaceutical regulatory guidance and expectations
Lilly seeks a skilled ADME / DMPK scientist who will:- Lead and innovate in a multidisciplinary team environment with primary responsibility for ADME studies to support preclinical and clinical development of the Lilly genetic medicines portfolio
- Integrate ADME, PK and PK/PD endpoints with discovery chemistry and biology data to guide preclinical drug design, optimization, and delivery strategies.
- Design, implement, and interpret hypothesis-driven studies to inform key ADME, PK/PD, and toxicokinetic (TK) questions
- Collaborate and innovate with cross-functional and interdisciplinary colleagues
- Lead the preparation of ADME portions of regulatory communications and documents to support clinical development, new drug applications, and line extensions and interact with global regulatory authorities
- Mentor and build relationships with colleagues at all levels through coaching and support
- Strong written and verbal communication skills, with the ability to constructively lead and influence teams
Basic Requirements:Ph.D. in Biochemistry/Biology/Pharmacokinetics/Bioengineering/Pharmacology or a related scientific field
Greater than five years of experience as a scientist in a pharmaceutical and/or biotechnology company in a role related to ADME or PK/PD
Additional Skills/Preferences:- Knowledge of DMPK and/or bioanalytical considerations for gene editing and/or gene therapy modalities
- Experience with PK/PD modeling and simulation
- Experience with targeted delivery and biodistribution of oligonucleotides and/or gene therapies
- Understanding of and experience with PCR, immunoassay, and/or LC/MS bioanalytical methodology
Additional Information:This is a full-time position located in Boston, MA.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$193,500 - $338,800
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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