VICE PRESIDENT, CLINICAL DEVELOPMENT - CARDIOVASCULARSUMMARY:The Vice President, Clinical Development - Cardiovascular is responsible for defining and driving the clinical development strategy for Ionis' cardiovascular portfolio and for contributing to enterprise-level development and portfolio decisions.
This role operates with a high degree of independence and accountability, directly influencing corporate strategy, portfolio prioritization, and investment decisions. The VP partners closely with senior leadership across Development, Research, Regulatory Affairs, and Commercial to ensure that clinical programs are scientifically rigorous, operationally executable, and positioned to deliver meaningful value to patients and the company.
The VP is accountable for advancing multiple clinical programs across stages of development, including phase 4 and post marketing studies, and for making complex, high-impact decisions in areas where data may be limited and risk is significant.
This role will report to the Senior Vice President, Global Cardiovascular Development and will manage direct reports.
RESPONSIBILITIES: - Maintain deep expertise in cardiovascular and cardiometabolic disease, including lipid disorders such as hypercholesterolemia, hypertriglyceridemia, and lipoprotein(a)-mediated risk.
- Apply current and emerging science in lipid biology and cardiovascular risk reduction to inform clinical development strategies and portfolio decisions.
- Guide development of clinical programs targeting lipid-modifying therapies, including selection of appropriate patient populations, biomarkers, and endpoints.
- Provide leadership on the design and interpretation of cardiovascular outcomes trials (CVOTs) and other studies evaluating impact on major adverse cardiovascular events (MACE).
- Integrate translational insights (e.g., mechanism of action, biomarker response, genetic validation) into clinical development plans to strengthen probability of success.
- Guide interpretation of complex clinical and biomarker data, including lipid parameters and cardiovascular risk markers, and translate findings into strategic program decisions.
REQUIREMENTS: - M.D. with significant experience in clinical development within the biopharmaceutical industry.
- Deep expertise in cardiovascular disease, with strong experience in lipid disorders and cardiometabolic disease (e.g., dyslipidemia, atherosclerosis, triglyceride metabolism, Lp(a)).
- Demonstrated success leading development of therapies targeting cardiovascular risk factors, including experience with lipid-modifying agents and/or outcomes-based clinical programs.
- Experience designing and interpreting studies involving lipid biomarkers, surrogate endpoints, and cardiovascular outcomes (e.g., MACE).
- Proven ability to translate mechanistic and translational science (including genetics and biomarker data) into clinical development strategy.
- Demonstrated success leading clinical development programs across multiple stages, including late-stage development.
- Proven ability to make high-quality decisions in complex, ambiguous situations with meaningful business impact.
- Experience influencing portfolio strategy and contributing to investment or prioritization decisions.
- Strong leadership and influencing skills, with the ability to drive outcomes across cross-functional teams.
- Experience interacting with regulatory agencies and external experts.
Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position; reference requisition #IONIS003999
Ionis offers an excellent benefits package! Follow this link for more details:
Ionis BenefitsFull Benefits Link: https://ionis.com/careers#:~:text=Highly%20competitive%20benefits
The pay scale for this position is $338,814 to $423,694
NO PHONE CALLS PLEASE. PRINCIPALS ONLY.
