Staff Scientist

Department
BSD MED - Genetic Medicine - Center for Chemical Biology and Therapeutics (CCBT)

Job Summary
The Staff Scientist will play a key role in supporting and advancing the research initiatives of CCBT. The ideal candidate will have expertise in medicinal chemistry, organic synthesis, chemical biology, fragment-based drug discovery, library screening, lead optimization, assay development, and will contribute to experimental design, project execution, data analysis, and scientific communication. This position provides an excellent opportunity to work in a dynamic and collaborative research environment while driving innovative therapeutic discoveries.

Responsibilities

• Lead the chemical biology efforts in the Therapeutic Core Facility.
• Design and perform experiments in areas such as fragment-based drug discovery, high-throughput screening, chemical synthesis, drug solubility, membrane permeability, liver microsome stability, PK/PD.
• Collaborate with faculty, postdocs, and students to facilitate research programs.
• Provide technical expertise, mentorship, and training to junior researchers.
• Participate in grant writing, manuscript preparation, patent application, and scientific presentations.
• Oversee research operations, equipment maintenance, and laboratory protocols of the Therapeutic Core.
• Support the development of the Therapeutic Core Facility by optimizing workflows and methodologies.
• Coordinate with external partners, core facilities, and funding agencies as needed.
• Train and supervise non-PhD level lab technicians/assistants.
• Follow all research safety regulations and ensure that the Therapeutic Core Facility operates in a safe environment.
• Assist the Center Directors in areas as needed.
• Serves as a resource for collecting data and performing analysis. Facilitates and promotes a research project by providing scientific or intellectual information.
• Develops laboratory protocols and training on new techniques. Manage, analyze and make recommendations on complex data sets for research.
• Performs other related work as needed.

Minimum Qualifications

Education:
Minimum requirements include a PhD in related field.

Work Experience:
Minimum requirements include knowledge and skills developed through 5-7 years of work experience in a related job discipline.

Certifications:

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Preferred Qualifications

Education:

• Ph.D. in Chemical Biology, Medicinal Chemistry, Pharmacology, or a related field.

Experience:

• Experience with organic synthesis.
• Experience with drug design.
• Experience with library synthesis and screening.
• Experience with assay development.
• Experience with molecular docking.
• Experience with liver microsome stability assay.
• Experience with PK/PD.
• Experience with protein expression and purification.

Preferred Competencies

• Strong experimental and analytical skills in protein biochemistry.
• Proven track record of scientific publications and research contributions.
• Excellent written and verbal communication skills.
• Ability to work independently and collaboratively in a multidisciplinary environment.
• Strong manuscript and proposal writing skills.
• Ability to work with people from different backgrounds.
• Strong problem-solving skills.

Application Documents

• Resume/CV (required)
• Cover Letter (required)

The University of Chicago uses AI-assisted tools to streamline and augment some recruitment processes; however, AI is not used to make hiring decisions.

When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application.

Job Family
Research

Role Impact
Individual Contributor

Scheduled Weekly Hours
40

Drug Test Required
No

Health Screen Required
No

Motor Vehicle Record Inquiry Required
No

Pay Rate Type
Salary

FLSA Status
Exempt

Pay Range
$80,000.00 - $100,000.00
The included pay rate or range represents the University's good faith estimate of the possible compensation offer for this role at the time of posting.

Benefits Eligible
Yes
The University of Chicago offers a wide range of benefits programs and resources for eligible employees, including health, retirement, and paid time off. Information about the benefit offerings can be found in the Benefits Guidebook.