PhD or equivalent in protein biochemistry, molecular biology, or related field with 5+ years of industry experience.
Hands-on experience in protein production and purification in a biotech or pharmaceutical setting.
Strong expertise in mammalian cell culture and transient transfection techniques.
Proficient with protein purification (FPLCs, Autosamplers) and analytical systems (UHPLCs).
Experience with biophysical characterization methods like BLI, SPR, or DLS.
Demonstrated ability to design and optimize experiments independently.
Strong organizational and communication skills, with a focus on scientific rigor.
Responsibilities
Design and execute workflows for recombinant protein production and purification.
Contribute to experiments aimed at improving throughput and data quality.
Collaborate with cross-functional teams to support integrated project execution.
Mentor junior team members and serve as a subject matter expert.
Maintain strong documentation practices and reproducible workflows.
Prepare study reports and present results to stakeholders.
Support continuous improvement of lab operations and workflows.
Benefits
Healthcare coverage.
Annual incentive program.
Retirement benefits.
Broad range of other benefits.
Full Job Description
Sr. Scientist, Protein & Cell Sciences
Position Summary:
Metaphore Biotechnologies is seeking a highly motivated Sr. Scientist to join our Protein Sciences team within Research and Discovery. This role will focus on protein expression, purification, and analytical characterization in support of platform development and therapeutic discovery programs. The ideal candidate will bring strong hands-on experience with mammalian expression systems, protein biochemistry, and assay development, along with the ability to work independently and collaborate effectively across a multidisciplinary team.
Key Responsibilities:
Design and execute workflows for recombinant protein production, including transient mammalian expression, purification, and quality assessment.
Contribute to the design, execution, and troubleshooting of experiments that improve throughput, reproducibility, and data quality.
Partner closely with Antibody Discovery, Antibody Engineering, Computational Biology, and other cross-functional teams to support integrated project execution.
Serve as a mentor to junior team members and a subject matter expert within the company in the areas of recombinant production and protein stability metrics.
Establish and maintain strong documentation practices, experimental rigor, and reproducible workflows.
Prepare study reports, summarize data, and present results clearly to internal stakeholders.
Support continuous improvement of lab operations, including the adoption of new methods, tools, and workflows as needed.
Required Qualifications:
PhD (or BS/MS degree with equivalent level of experience) in protein biochemistry, molecular biology, chemical engineering, structural biology, analytical chemistry, or a related field with 5+ years of industry experience.
Experience in protein production, purification, and analytical characterization in a biotechnology or pharmaceutical setting responsible for regular production of milligram to grams of material on a reoccurring weekly basis.
Strong hands-on experience with mammalian cell culture and transient transfection.
Proficiency with protein purification systems (FPLCs and Autosamplers) and analytical systems (UHPLCs) used to assess protein quality and function.
Experience with biophysical characterization methods such as BLI, SPR, DSF, DLS, or related approaches.
Demonstrated ability to design, troubleshoot, and optimize experiments independently.
Strong organizational skills, scientific rigor, and written and verbal communication skills and a record of establishing robust systems
Ability to work effectively in a fast-paced, collaborative, cross-functional environment.
Preferred Qualifications:
Experience with antibody discovery workflows and biologics development.
Experience with automated multi-step midscale purification.
Experience with production from linear DNA templates.
Experience with bi and multi specific antibody formats.
Experience managing direct reports or mentoring junior scientists.
Familiarity with data capture systems and structured documentation practices.
Exposure to assay development and validation for discovery or translational applications.
The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Metaphore Biotechnologies, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Metaphore Biotechnologies, Inc.'s good faith estimate as of the date of publication and may be modified in the future.
About Flagship Pioneering
Flagship Pioneering is a life sciences innovation enterprise that conceives, creates, resources, and develops first-in-category life sciences companies. The firm operates through its Flagship Labs unit, which is a dedicated innovation foundry that invents and launches transformative companies. Flagship Pioneering has created over 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. The firm's portfolio includes companies in the fields of therapeutics, health technologies, and sustainability. Flagship Pioneering was founded in 2000 and is headquartered in Cambridge, Massachusetts.
