5+ years of advanced TypeScript/JavaScript/Python development expertise.
Extensive experience with Node.js and NestJS frameworks.
Proven React development skills with complex component design.
Experience in building and maintaining bioinformatics orchestration pipelines using Nextflow.
Hands-on experience with Seqera Platform for workflow management in cloud environments.
Advanced PostgreSQL skills, including optimization and performance tuning.
Expertise in implementing Redis caching solutions for high-throughput systems.
Responsibilities
Lead the analysis and design of complex technical problems.
Architect robust systems for genomic data processing.
Mentor emerging talent within the engineering team.
Craft high-quality code and scale genomic data processing pipelines.
Integrate APIs into user-facing applications and embed workflows into core products.
Leverage modern AI tooling to enhance development processes.
Drive cross-team technical initiatives and resolve engineering challenges.
Benefits
Full range of benefits including medical and other health-related options.
Incentive compensation and restricted stock units may be offered.
Full Job Description
About the Role
We are seeking a highly motivated and capable Senior Software Engineer to help advance our Diagnostics initiatives. In this role, you will lead the analysis and design of complex technical problems, architect robust systems, and mentor emerging talent. This position requires deep expertise in full-stack engineering, relational data systems, bioinformatic workflow orchestration, and algorithmic development. As a senior technical leader, you will be expected to craft high-quality code, scale genomic data processing pipelines, leverage modern AI tooling, integrate APIs into user-facing applications, and embed agentic workflows into our core product ecosystem.
Technical Requirements
5+ years of advanced TypeScript/JavaScript/python development with a deep understanding of language features and optimization techniques.
Extensive experience architecting and leading development with Node.js and NestJS frameworks.
Experience with React development with a demonstrated ability to design and implement complex component systems.
Proven experience building, scaling, and maintaining bioinformatics orchestration pipelines for high-throughput genomic data analysis using workflow frameworks such as Nextflow.
Hands-on experience managing, monitoring, and optimizing workflow executions via Seqera Platform (Nextflow Tower) across cloud environments.
Hands-on experience leveraging GenAI coding tools and autonomous agents (e.g., Copilot, Cursor, LLM APIs) to accelerate development, refactor codebases, and auto-generate comprehensive unit/integration tests.
Experience or strong working knowledge of integrating APIs and GenAI technologies into production applications.
Advanced PostgreSQL skills including query optimization, indexing strategies, and performance tuning.
Proven expertise implementing sophisticated Redis caching solutions for high-throughput systems.
Demonstrated success designing and implementing distributed microservice architectures that seamlessly interface with data-intensive bioinformatic workflows.
Significant experience orchestrating infrastructure and applications on GCP, including CI/CD pipelines and cloud-based compute backends for pipeline execution.
Mastery of enterprise-level design patterns and their practical application in large-scale, mission-critical systems.
What Makes You a Great Fit
7+ years of software development experience with a track record of technical leadership.
Ability to make high-impact architectural decisions that balance business needs, data infrastructure constraints, and scientific computing requirements.
Track record of bridging the gap between software engineering and computational biology/bioinformatics teams to streamline workflow execution and data delivery.
Enthusiasm for championing AI-assisted development practices, driving adoption of agentic workflows, and mentoring teams through the evolving landscape of AI tools.
History of successfully delivering complex projects in fast-paced environments.
Strong communication skills with experience presenting technical solutions to diverse stakeholders.
Proven ability to drive cross-team technical initiatives and resolve complex engineering challenges.
Bonus Points
Advanced expertise in Nextflow (DSL2) custom module/subworkflow development and integration with cloud-native storage/compute engines (e.g., GCP Batch, Life Sciences API, or AWS Batch).
Experience with search technologies such as Elasticsearch or OpenSearch.
Experience with containerization orchestration (Docker, Kubernetes).
Background in biotech, genomics, or precision medicine.
CHI: $110,000-$160,000
The expected salary range may vary for other locations. Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.
About Tempus
Tempus is a technology company that has built an operating system to battle cancer. The company enables physicians to deliver personalized cancer care for patients through its interactive analytical and machine learning platform. Tempus provides genomic sequencing services and analyzes molecular and therapeutic data to empower physicians to make real-time, data-driven decisions. The company also offers research services to enable discovery of new therapeutic targets and clinical services that support clinical trial design and monitoring. Tempus was founded in 2015 by Eric Lefkofsky and has raised over $8 billion in funding to date.
