The Neuroscience TRC is committed to the development of transformational therapeutics for patients with neurodegenerative, neuromuscular and neuropsychiatric diseases. A network of internal and external partnerships across neurodegenerative and neuropsychiatric diseases and treatment modalities (small molecules, biologics and genetic medicines) supports our ambition to become leaders in neuroscience. Internal research focuses on causal human biology, matching therapeutic modality to molecular mechanism, and translational discovery enabling a rapid path to clinical proof-of-concept.
In the role as a Senior Scientist within In Vivo Pharmacology, the ideal candidate:
- Performs and directs in vivo pharmacology studies in mice, inclusive of in-life dosing (IV, SC, IP, PO, ICV), tissue collection, and tissue processing
- Performs and analyzes pharmacodynamic (PD) and efficacy readouts, including mRNA/protein expression levels, neuropathology, transcriptomics, and physiology
- Develops new assays and mouse models as needed
- Manages in vivo studies conducted at contract research organizations (CROs)
- Serves as an in vivo pharmacology representative or biology lead on program and platform teams, and as such, contributes to program strategy
- Participates in the evaluations of external assets and technologies as needed
Basic Qualifications:- Bachelor's Degree
- 7+ years of academic and / or industry experience
Or
- Master's Degree
- 5+ years of academic and / or industry experience
Or
- Ph.D. or equivalent advanced degree in the Life Sciences
- 2+ of academic and / or industry experience
Preferred Qualifications: - PhD in Neuroscience or related field is required.
- Extensive expertise and practical experience in genetic medicines, particularly the delivery of siRNAs and/or ASOs across the blood-brain barrier (BBB), is required.
- Expertise and practical experience in one or more of the following areas:
- Neurodegenerative disease, such as Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease, particularly with respect to animal modeling
- Neuromuscular disease, such as amyotrophic lateral sclerosis (ALS) and muscular dystrophies, particularly with respect to animal modeling
- RNA biology and splice modulation
- Extensive mouse handling experience, including common dosing routes and tissue collection from central nervous system (CNS) and peripheral tissues required
- Proficiency in standard molecular biology, biochemical, immunohistochemical, and/or muscle physiology assays required
- Experience with rodent stereotaxic surgery
- Familiarity with in vivo bioluminescence imaging
- Familiarity with transcriptomics and/or proteomics
- Experience working with contract research organization (CROs)
- Strong organizational and communication skills
- Ability to work independently and as part of a team
- Detail-oriented with a commitment to scientific rigor and reproducibility
- Adaptability in a fast-paced, collaborative research environment
We hire for skills and capabilities, not just credentials - if this role excites you, but doesn't perfectly match your resume, we encourage you to apply anyway.
Compensation Overview:Cambridge Crossing: $137,570 - $166,706
The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully - carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.
Benefits:Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans - including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).
U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.
Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.
Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.
U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits
How We WorkWhere you work matters - because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.
R1607298 : Senior Scientist, In Vivo Pharmacology, Neuroscience
