Career CategoryScientific
Job DescriptionSenior Scientist - Computational Protein DesignWhat you will doLet's do this. Let's change the world. In this vital role you will develop and deploy automated computational pipelines for large-scale binder design, supporting the creation of diverse design candidates and libraries across multiple targets. Your work will directly enable discovery efforts by accelerating the generation of molecules used to probe novel biology and deliver new biological insights.
Key Responsibilities:
- Develop and automate ML protein design workflows for binder generation
- Build scalable pipelines for designing large libraries of de novo proteins across multiple targets
- Apply computational methods to support multiplexed screening strategies and receptor discovery efforts
- Design and prioritize binders for individual targets and large target panels
- Contribute to shared tools, workflows, and best practices within the protein design community
- Collaborate closely with experimental scientists and data teams to enable rapid validation and iteration
What we expect of youWe are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a Researcher with these qualifications.
Basic Qualifications:Doctorate degree PhD
OR PharmD
OR MD [and relevant post-doc experience in Computational Biology, Structural Biology, Bioengineering, Biophysics, Computer Science, or related discipline with a focus on protein design]
OR
Master's degree and 3 years of protein design experience
OR
Bachelor's degree and 5 years of protein design experience
Preferred Qualifications:- Ph.D. with postdoc in Computational Biology, Structural Biology, Bioengineering, Biophysics, Computer Science, or related discipline with a focus on protein design.
- Demonstrated experience in computational protein design, including the design of binders such as minibinders and/or antibodies.
- Experience developing automated and scalable computational pipelines for protein design or structural modeling, ideally in high-throughput environments.
- Familiarity with modern AI/ML-driven protein design and structure prediction tools (e.g., AlphaFold, ProteinMPNN, RFdiffusion, or similar frameworks).
- Strong programming skills in Python and/or other scripting languages, with experience building maintainable workflows and automation for large-scale computational experiments.
- Experience working with large protein libraries or multiplexed design strategies, including design filtering, ranking, and diversity optimization.
- Knowledge of protein structure-function relationships, epitope targeting strategies, and protein-protein interaction design principles.
- Experience integrating computational design outputs with experimental validation workflows, including library generation, screening, or directed evolution approaches.
- Familiarity with cloud computing, high-performance computing (HPC), and workflow orchestration tools.
- Experience collaborating in cross-functional teams spanning computational scientists, experimental biologists, and data scientists.
- Strong communication skills and ability to contribute to a collaborative protein design community, including sharing tools, best practices, and design insights.
What you can expect from usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
Apply now and make a lasting impact with the Amgen team.careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadlineAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
SponsorshipSponsorship for this role is not guaranteed.
Salary Range146,404.00USD -198,076.00 USD
