Degree in Chemistry, Biochemical Engineering, Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology, or related field (B.S. with 14+ years, M.S. with 12+, or Ph.D. with 5+ years of relevant experience).
Hands-on experience with mRNA/DNA cargo and LNP products.
Technical expertise in HPLC separations or LC-MS, with a proven track record in method development and troubleshooting.
Experience with plate-based assays is a plus.
Demonstrated ability to design, execute, and troubleshoot complex experiments independently.
Experience mentoring or providing technical guidance to junior staff is desired.
Strong communication and organizational skills, with proficiency in Benchling, MS Office, JMP, GraphPad, Empower, and Chromeleon.
Responsibilities
Lead method development and implementation for nucleic acid cargo and LNP product release, stability, and characterization.
Conduct experimental studies to optimize analytical methods for specificity, sensitivity, precision, accuracy, and linearity.
Troubleshoot assay development and instrument operation issues, serving as a technical resource for the team.
Plan experiments, design studies, and schedule development projects and routine testing.
Support analytical analysis for process development activities to ensure robust characterization.
Work independently and collaboratively in a multidisciplinary team, providing mentorship to junior colleagues.
Analyze and communicate experimental findings clearly in various formats to internal teams and stakeholders.
Benefits
Healthcare coverage
Annual incentive program
Retirement benefits
Broad range of other benefits
Full Job Description
Position Summary:
We are seeking a highly motivated and experienced candidate for a role of Senior Scientist on the Analytical Development and Quality Control team. This candidate will lead method development, optimization, and qualification efforts to support characterization of novel nucleic acid therapeutics and LNP delivery vehicles, and will mentor junior team members as part of this role. We are looking for an individual who enjoys hands-on laboratory benchwork and brings scientific rigor and intellectual curiosity to their role. This individual will have the opportunity to work in a dynamic and fast-paced entrepreneurial environment as part of a highly collaborative and rapidly growing team.
Key Responsibilities:
Lead the team's advancement of platform development and play a vital role in shaping our analytical capabilities. Step into benchwork to execute platform goals with tenacity and agility, while providing technical direction and mentorship to junior team members.
Lead method development and implementation to support nucleic acid cargo and LNP product release, stability and characterization
Lead experimental studies to optimize specificity, sensitivity, precision, accuracy, and/or linearity of analytical methods
Troubleshoot assay development and instrument operation issues, serving as a technical resource for the broader team
Experimental planning, study design and scheduling of development projects as well as routine testing across programs
Support day-to-day execution of analytical analysis for process development activities to ensure robust process and product characterization
Work independently and collaboratively in a multidisciplinary team environment, providing technical guidance and mentorship to junior colleagues
Analyze, troubleshoot, and communicate experimental findings clearly and succinctly in oral, written, and visual formats to internal teams and cross-functional stakeholders
Provide technical input to support regulatory filings
Author and manage protocols, laboratory data, and technical reports
Qualifications:
Degree in Chemistry, Biochemical Engineering, Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology or related field. B.S. degree with 14+ years, M.S. degree with 12+, or Ph.D. with 5+ years of relevant industry experience.
Prior hands-on experience working with mRNA/DNA cargo and LNP products
Demonstrated technical expertise in HPLC separations or LC-MS, with a track record of independently developing and troubleshooting analytical methods
Experience with plate-based assays is a plus
Proven ability to independently design, execute, and troubleshoot complex experiments
Experience mentoring, training, or providing technical guidance to junior staff is desired
Strong communication and organization skills; good working knowledge of Benchling, MS Office, JMP, GraphPad, Empower, Chromeleon
Demonstrates attention to detail, meticulous record keeping and personal organization
Ability to analyze, compile, and present experimental data in oral presentations as well as in technical reports
Strong technical writing skills to support method SOPs, protocols, and reports
Ability to lead cross-functional technical initiatives and represent the ADQC team in scientific discussions
The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Serif Biomedicines's good faith estimate as of the date of publication and may be modified in the future.
