UT MD Anderson seeks a Senior Research Scientist to contribute to groundbreaking translational research focused on advanced prostate cancer, tumor microenvironment biology, immuno-oncology, therapeutic resistance, and extracellular vesicle (EV)-based biomarker discovery. The Senior Research Scientist will lead laboratory and translational studies utilizing patient-derived specimens, molecular and immune profiling, EV technologies, and clinically relevant preclinical models. Within GU Medical Oncology, the Senior Research Scientist will play a key role in advancing scientific knowledge and translating discoveries into clinically actionable strategies.
The ideal candidate will have substantial experience in translational oncology and cancer immunology, including experience working within multidisciplinary research environments. Familiarity with MD Anderson research infrastructure, institutional processes, collaborative team science, and translational therapeutic development is highly desirable. Demonstrated ability to independently lead research initiatives, mentor trainees, and contribute to scientific publications and grant development is preferred.
Responsibilities
Advance Scientific Discovery
• Lead translational research in advanced prostate cancer, tumor microenvironment biology, immuno-oncology, therapeutic resistance, and EV-based biomarker discovery
• Investigate mechanisms of tumor progression, immune regulation, EV-mediated communication, and treatment resistance
• Generate clinically actionable insights that advance precision oncology and therapeutic development
• Translate laboratory discoveries into strategies that improve patient outcomes in genitourinary cancer
Research Design & Experimental Studies
• Design and conduct experimental studies in cancer biology, immunology, molecular profiling, and biomarker development
• Develop and optimize platforms for EV research, biomarker discovery, and tumor microenvironment studies
• Utilize patient-derived specimens, molecular profiling approaches, and immune profiling technologies in translational studies
• Develop immune profiling and monitoring approaches using patient-derived biospecimens and translational research platforms
Preclinical & Therapeutic Development
• Evaluate clinically relevant preclinical models to investigate treatment response and resistance
• Assess therapeutic strategies and mechanisms associated with treatment outcomes
• Support translational efforts that bridge laboratory findings with clinical research applications
Collaboration & Scientific Communication
• Collaborate with investigators and clinicians to advance translational and clinical research initiatives
• Participate in departmental and institutional research programs and collaborative activities
• Prepare manuscripts, presentations, reports, and grant applications to disseminate research findings
• Contribute scientific expertise to multidisciplinary research efforts and strategic initiatives
Leadership & Mentorship
• Mentor trainees and research staff and provide scientific guidance
• Foster development of research personnel through training and knowledge sharing
• Support a collaborative and productive research environment
• Perform other duties as assigned
EDUCATION:
Required: Master's Degree Natural sciences or related field.
Preferred: PhD Natural sciences or Medical Degree
EXPERIENCE:
Required: Six years experimental or scientific work experience, With PhD or Medical degree, three years experimental or scientific work experience.
Preferred: Experience in cancer immunology, immuno-oncology, advanced prostate cancer biology, tumor microenvironment research, therapeutic resistance, immune monitoring, biomarker development, and translational research. Experience with flow cytometry, patient-derived biospecimens, preclinical cancer models, molecular profiling technologies, and multidisciplinary translational research programs is highly desirable. Prior experience within a large academic cancer center is preferred.
The University of Texas MD Anderson Cancer Center offers excellent benefits, including medical, dental, paid time off, retirement, tuition benefits, educational opportunities, and individual and team recognition.
This position may be responsible for maintaining the security and integrity of critical infrastructure, as defined in Section 113.001(2) of the Texas Business and Commerce Code and therefore may require routine reviews and screening. The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment.
