Our Team, Your ImpactWe are seeking a
Senior Research Associate to join our
Cell Culture Process Development team within
Biologics CMC in West Chester, PA. This is a hands-on, lab-based role ideal for a motivated candidate with a strong foundation in mammalian cell culture and a passion for innovation in complex biologics production.
You will execute mammalian cell culture studies independently, perform data analysis to drive process decisions, and help develop robust, scalable, and manufacturable cell culture processes for therapeutic proteins. The role spans early and late-stage development to support clinical and commercial manufacturing. The role offers meaningful contribution to meeting program milestones, and exposure to high-throughput bioreactor systems, pilot-scale operations, modern automation and data modeling tools, and collaboration across the biologics CMC organization.
How You'll Spend Your Day- Independently design, execute, analyze, and document mammalian cell culture experiments based on sound scientific principles and clear experimental objectives.
- Contribute to the development and optimization of robust cell culture and harvest processes, including media and feeding strategies, to improve process performance, productivity, and product quality.
- Independently operate and troubleshoot mammalian cell culture systems across scales, including shake flasks, high-throughput and automated bioreactors, bench-scale bioreactors, and pilot-scale equipment
- Use DOEs, multivariate analysis, data modeling and digital tools to identify critical process relationships and enable data-driven decisions.
- Interpret experimental results and communicate scientifically sound conclusions and recommendations through technical reports, protocols, presentations, and cross-functional discussions.
- Promote safe laboratory practices, data integrity, high-quality documentation, continuous improvement, and an inclusive team environment.
Your Skills and Experience- M.S or B.S. in Chemical/Biochemical Engineering, Cell Biology, or related field with 2+ years of relevant industry experience.
- Hands-on experience with mammalian suspension cell culture and bioreactor-based process development for recombinant proteins or other biologics.
- Demonstrated ability to independently execute experiments, analyze complex data, troubleshoot technical challenges, and draw clear, defensible conclusions with minimal supervision.
- Clear written and verbal communication skills and the ability to collaborate effectively in a matrixed, multidisciplinary environment.
What Success Looks Like - You contribute to well-designed, reproducible studies that answer important development questions and support timely program decisions.
- You translate experimental results into clear recommendations for robust, scalable, and manufacturable cell culture processes.
- You become a trusted member of the CCPD team, and contribute to a culture of scientific rigor, ownership, and continuous learning.
Also Good to Have- Experience with CHO cell culture, fed-batch processes, automated or high-throughput bioreactor platforms, and continuous centrifugation.
- Experience with process scale-up and/or scale-down, process characterization, and pilot-scale production.
- Proficiency with statistical applications such as JMP and or SIMCA and practical use of DoE or multivariate analysis.
- Familiarity with cGMP principles, data integrity expectations, and technical documentation for biologics development.
How We'll Take Care of YouWe offer a competitive benefits package, including:
- Comprehensive Health Insurance: Medical, Dental, Vision, and Prescription coverage starting on the first day of employment, providing the employee enrolls.
- Retirement Savings: 401(k) with employer match, up to 6% and an annual 3.75% Defined Contribution to the 401k plan.
- Time Off: Paid Time Off including vacation, sick/safe time, caretaker time and holidays.
- Life and Disability Protection: Company paid Life and Disability insurance.
- Additional benefits include, but are not limited to, Employee Assistance Program, Employee Stock Purchase Plan, Tuition Assistance, Flexible Spending Accounts, Health Savings Account, Life Style Spending Account, Volunteer Time Off, Paid Parental Leave, if eligible , Family Building Benefits, Virtual Physical Therapy, Accident, Critical Illness and Hospital Indemnity Insurances, Identity Theft Protection, Legal Plan, Voluntary Life Insurance and Long Term Disability and more.
The total compensation may also include restricted stock units and discretionary awards, depending on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment.
Make sure to apply through our internal career site on Twist-your one-stop shop for career development
