SUMMARYWe are seeking a Senior Director/Vice President of Translational Medicine and Pharmacology to serve as a scientific leader driving translational strategy across Immunic's pipeline of selective, orally available immunology therapies. Reporting to the Chief Medical Officer, this role will play a critical part in advancing biomarker strategy, mechanism of action characterization, and translational pharmacology for the Phase 3 vidofludimus calcium program in multiple sclerosis, while shaping translational strategy for earlier-stage pipeline assets. You will bring deep translational science expertise, a track record of biomarker-driven clinical development, and the ability to operate effectively in a lean, cross-functional biotech environment.
RESPONSIBILITIES- Lead translational medicine and pharmacology strategy across Immunic's pipeline, initially with primary focus on the Phase 3 vidofludimus calcium program in relapsing and progressive multiple sclerosis
- Design and oversee biomarker strategies, including pharmacodynamic, efficacy, safety, and patient stratification biomarkers, integrated into clinical trial protocols
- Partner with Clinical Development, Clinical Pharmacology, and Biostatistics to translate preclinical pharmacology data into clinical dosing rationale and study design
- Serve as the scientific lead for mechanism of action, PK/PD modeling, and exposure-response analyses supporting clinical and regulatory decision-making
- Collaborate with Regulatory Affairs to develop translational and pharmacology sections of IND/CTA submissions, briefing documents, and BLA/NDA packages
- Support and present at health authority meetings (e.g., FDA, EMA) on translational and pharmacology topics, responding to agency queries with scientific rigor and strategic clarity
- Partner with Discovery and Preclinical teams to guide selection and advancement of early-stage pipeline assets based on translational rationale and mechanism of action
- Partner with Medical Affairs and Clinical Development to drive the development and review of translational publications and conference presentations
- Identify and develop relationships with MS experts, translational researchers, academic centers, and key opinion leaders in immunology and neurology
- Contribute to business development activities by evaluating in-licensing opportunities and supporting scientific due diligence efforts
- Help build and mentor a high-performing translational medicine function as the company evolves
QUALIFICATIONS & EXPERIENCE- MD/PhD required; Minimum 12 years of translational medicine, clinical pharmacology, or related experience in the pharmaceutical or biotechnology industry
- Demonstrated experience in neurology, immunology and/or autoimmune disease, ideally with a focus on multiple sclerosis
- Proven track record of applying biomarker and translational strategies to advance programs through clinical development to regulatory submission
- Deep understanding of PK/PD modeling, exposure-response analysis, and FDA/EMA regulatory expectations for translational data packages
- Experience leading or supporting health authority interactions on translational and pharmacology topics
- Strong cross-functional collaboration skills with the ability to influence without authority in a matrixed organization
- Excellent written and verbal communication skills; experience presenting to executive leadership and scientific audiences
- Comfort operating in a small-company environment with a high degree of autonomy and accountability; comfortable with ambiguity
- Willingness to travel internationally, including periodic travel to Immunic's operations in Germany
