Eli Lilly

Senior Director, DMPK Project Leader

Eli Lilly$177K — $338K *
US-AnywhereRemote in United States
Pharmaceuticals & Biotech
8 - 10 years of experience
Job Overview by Ladders

Qualifications

  • Ph.D. in Pharmaceutical Sciences, Pharmacology or a related field
  • Minimum of 10 years of industry experience in biotech or pharmaceutical settings
  • Expert in DMPK sciences and drug development processes
  • Strong analytical and problem-solving skills
  • Experience in leading DMPK projects
  • Previous experience with CNS drug candidates
  • Familiarity with regulatory submissions, particularly NDAs for small molecules

Responsibilities

  • Lead NDA filings for DMPK-related activities
  • Deliver timely high-quality DMPK data and insights to projects
  • Utilize DMPK knowledge to influence compound profiling and project strategies
  • Estimate PK and toxicokinetic parameters and report findings
  • Coordinate across DMPK, clinical pharmacology, and toxicology teams
  • Prepare presentations for internal governance meetings

Benefits

  • Participation in a company-sponsored 401(k) and pension plan
  • Comprehensive medical, dental, and vision benefits
  • Flexible spending accounts for healthcare and dependent care
  • Life insurance and death benefits
  • Various paid time off and leave of absence options
  • Well-being benefits including employee assistance and fitness programs
Full Job Description
Description of Role

Senior Director, DMPK Project Leader ensures delivery of all DMPK related activities working collaboratively as part of a cross-functional program team. These include nonclinical PK experiments, in vitro ADME, biotransformation studies, bioanalytical and toxicokinetic analysis. This role supports understanding pharmacokinetic, toxicokinetic, and ADME principles to enable progression of drug candidates across the portfolio. A qualified candidate will have previous experience in PK modeling ideally for CNS drug candidates and a basic understanding of vital ADME properties for CNS drug candidate progression. Furthermore, a qualified candidate will have end-to-end experience in drug discovery and development including NDA submission; will be able to partner with both discovery and development teams to enable the identification of lead candidates with optimal DMPK properties for progression into nonclinical development and the progression of lead candidates into clinical development.

Key Responsibilities

  • Lead the filing of NDAs for DMPK


  • Deliver high-quality DMPK input and data to projects within established timelines


  • Utilize knowledge of DMPK to support/influence compound profiling, project progression and project strategy


  • Proactively calculate PK and toxicokinetic parameters, estimate safety margins and report results and interpretations to project teams and internal governance bodies


  • Lead, coordinate, and engage with DMPK colleagues, clinical pharmacologists, and toxicologists in project related activities


  • Prepare clear presentations related to the above for internal governance bodies


Qualifications

  • Ph.D. in Pharmaceutical Sciences, Pharmacology or a related field


  • Minimum of 10 years of industry experience in a biotech or pharmaceutical setting


  • Expert in DMPK sciences with knowledge of drug discovery and development processes


  • Strong analytical and problem-solving skills


  • Experience in DMPK project leadership


  • Previous work in the discovery and/or development of CNS drug candidates


  • Experience with regulatory submissions including NDAs for small molecules


  • Knowledge, experience, and proficiency in supporting GLP-compliant studies


  • Good knowledge of all DMPK assays including the use of in silico tools for PK prediction


  • Proficiency with Phoenix WinNonlin and other software for NCA and PK modeling in small molecule drug discovery and development


  • Demonstrated ability to work cross-functionally and communicate scientific findings clearly and effectively


  • Collaborative mindset and operates with a sense of urgency


  • Strong, proactive communication skills


Work Location

The Senior Director, DMPK Project Lead role based in the US, with occasional travel.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$177,000 - $338,800

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

About Eli Lilly

ICOS Corporation is a biotechnology company that engages in the discovery, development, and commercialization of therapeutic products. It is engaged in the commercialization of treatments for unmet medical conditions, such as benign prostatic hyperplasia, hypertension, pulmonary arterial hypertension, cancer, and inflammatory diseases. It is the developer of a treatment known as Cialis (tadalafil), a product for the treatment of erectile dysfunction through its joint venture with Eli Lilly and Company in North America and Europe. It is also engaged in contract manufacturing services for third parties. It is in a strategic alliance with Solvay Pharmaceuticals, Inc. ICOS Corporation was established in 1989, based in Bothell, Washington. It is currently operated by Eli Lilly and Company.

Eli Lilly Careers

Joining Eli Lilly offers an unparalleled opportunity to become part of a leading global team dedicated to creating a healthier future. As a company revered for its commitment to innovation and leadership in the pharmaceutical industry, Eli Lilly is where your professional journey can flourish. Work You’ll Do At Eli Lilly, we are passionate about transforming patient care and advancing medical innovation. Our team at Eli Lilly is at the forefront of developing groundbreaking solutions in healthcare. By joining us, you will collaborate with some of the brightest minds in the industry, using cutting-edge technology to make real-world impacts. Lead with Innovation and Leadership Eli Lilly stands out in the marketplace by integrating deep industry expertise with robust research and development efforts. We are looking for professionals who are eager to drive change and lead the way in developing therapeutic breakthroughs. Explore Job Opportunities and Growth Eli Lilly offers a variety of career paths, including full-time positions and internships, across multiple functions such as research, marketing, IT, and sales. Whether you are a seasoned professional or a recent graduate, Eli Lilly provides an environment that promotes career growth and learning opportunities. Our commitment to diversity and leadership training ensures that every employee can achieve their potential. Be Part of Our Team Our team at Eli Lilly is committed to excellence and driven by a mission to improve lives. Employees enjoy a supportive culture that values collaboration, creativity, and diversity. We believe that a diverse workforce fosters innovation and helps us better connect with the communities we serve. Benefits and Culture Eli Lilly is dedicated to supporting our employees, offering competitive benefits, wellness programs, and comprehensive health care. Our culture is built on a foundation of respect, integrity, and quality, making Eli Lilly not just a great place to work, but a community to grow with. Networking and Professional Development Eli Lilly encourages continuous professional development and networking. With access to various training programs and mentorship opportunities, employees can enhance their skills and advance their careers. Our leadership is committed to nurturing talent through effective training and development strategies. Join Our Team Discover the exciting job opportunities at Eli Lilly by exploring open positions that match your skills and interests. We are continuously hiring and looking for individuals who are passionate, innovative, and ready to contribute to our mission of making life better for people around the globe. Stay Connected Keep up to date with the latest at Eli Lilly by following our careers blog. Gain insights from industry leaders and get tips on everything from crafting the perfect resume to preparing for your interview. Eli Lilly is not just a company—it's a place where you can make a difference. Explore the positions available and find out how your talents can help change the world. SEARCH ELI LILLY JOBS Stay ahead in your career with Eli Lilly, where innovation, leadership, and a commitment to diversity and growth lead the way to future advancements.
Learn more about Eli Lilly
Size
35,000 employees
Market Cap
$344.2 billion
Industry
Net Income
$6.1 billion
Founded
1876
5 Year Trend
+5.9%
Revenue
$24.5 billion
NASDAQ

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