DescriptionHeadquarters Location: Emeryville, CA
Candidate Location: Hybrid
Travel Required: 10%
Reports To: VP, Clinical Development
Department: Clinical Development
Position Type: Full-time, Exempt
Who You Are and What You'll Do:You are passionate about life sciences and making a difference to cancer patients, their families, and healthcare providers. As Senior Director, Clinical Science, you will provide strategic and scientific leadership for one or more oncology programs spanning early- through late-stage clinical development. You will collaborate across functions to translate emerging safety, efficacy, pharmacology, biomarker, and operational data into clear recommendations that advance clinical strategy and study execution.
Your immediate priorities will include leading integrated clinical data review for assigned studies, strengthening scientific interpretation and decision-making, supporting high-quality study execution, and preparing clinical-science deliverables for upcoming development and regulatory decisions.
Job Responsibilities: - Provide scientific leadership for the design, execution, interpretation, and communication of clinical studies across Phase 1 through Phase 3 oncology development programs, based on assigned program needs.
- Lead the development and review of protocols, protocol amendments, investigator materials, clinical study reports, regulatory content, and internal clinical-development materials.
- Integrate efficacy, safety, pharmacokinetic, pharmacodynamic, biomarker, and operational data to identify trends, risks, opportunities, and implications for clinical strategy.
- Lead ongoing clinical data review in collaboration with Clinical Operations, Biostatistics, Data Management, Pharmacovigilance, Regulatory Affairs, Translational Medicine, and other relevant functions.
- Develop and clearly communicate scientifically grounded recommendations regarding study design, patient populations, endpoints, dose and schedule, data analyses, and future development options.
- Serve as a senior Clinical Science representative on study and program teams, facilitating alignment, timely decisions, and clear accountability.
- Anticipate complex clinical-program risks, convene the appropriate stakeholders to evaluate options, and recommend a timely path forward.
- Contribute to clinical-development plans and short- and long-range program strategy based on emerging evidence, the evolving treatment landscape, and patient needs.
- Support interactions with investigators, external experts, partners, vendors, and regulatory authorities, as appropriate.
- Communicate complex clinical and scientific information clearly to executive leaders, governance bodies, cross-functional teams, investigators, and other external audiences.
- Coach and mentor clinical scientists and other colleagues through scientific expertise and cross-functional leadership, without direct people-management responsibility.
- Maintain current knowledge of oncology standards of care, emerging scientific evidence, the competitive landscape, and applicable regulatory guidance.
- Perform responsibilities in accordance with applicable regulations, quality standards, company policies, and ethical requirements.
Minimum Qualifications: - MD, PharmD, PhD, or an equivalent advanced degree in medicine, pharmacy, life sciences, or a related discipline.
- At least 10 years of relevant biotechnology or pharmaceutical industry experience, including at least 7 years of direct clinical-development experience. An equivalent combination of education and experience may be considered.
Preferred Qualifications: - Clinical-development experience in oncology, including meaningful experience with the design, execution, analysis, and interpretation of interventional clinical studies.
- Demonstrated ability to lead complex clinical-science deliverables and influence multidisciplinary stakeholders in an individual-contributor capacity.
- Experience integrating clinical safety, efficacy, pharmacology, biomarker, and operational information into scientifically grounded development recommendations.
- Strong knowledge of clinical trial methodology, clinical data review, scientific documentation, and applicable regulatory and quality expectations.
- Experience developing or contributing to protocols, clinical study reports, regulatory documents, or other major clinical-development deliverables.
- Ability to communicate complex scientific and clinical information clearly, concisely, and persuasively to technical and nontechnical audiences.
- MD or MD/PhD with relevant oncology clinical-development experience.
- Experience spanning both early- and late-stage oncology clinical development.
- Experience contributing to regulatory interactions, clinical-development plans, or major regulatory submissions.
- Experience supporting dose optimization, benefit-risk assessment, and development of clinical data-review strategies.
- Experience integrating biomarkers, translational findings, or patient-selection strategies into clinical-development decisions.
- Experience with antibody-drug conjugates, T-cell engagers, immuno-oncology agents, cytokines, or other complex oncology therapeutic modalities.
- Experience supporting global or multicenter clinical studies.
- Experience presenting clinical data to governance bodies, investigators, regulatory authorities, or external scientific audiences.
- Experience coaching and mentoring clinical-science colleagues.
- Experience working effectively in a collaborative biotechnology environment with evolving priorities and resource constraints.
How You Will Work:- Demonstrates collaboration and teamwork. Works well with others and understands that collaboration leads to better results.
- Possesses strong communication skills. Communicates clearly, concisely, and professionally. Listens actively to build understanding.
- Exhibits strong interpersonal skills and self-awareness. Builds and cultivates strong and enduring relationships with others. Acts with humility and understands own strengths and weaknesses.
- Shows continuous improvement and a commitment to self-management and development. Operates with a continuous improvement mindset and continuously seeks to expand own knowledge and capabilities.
- Demonstrates a patient focus. Puts the patient first in actions and decisions taken.
- Contributes to strategy and innovation. Contributes to or leads elevating and actionable strategies. Ideates and creates unique opportunities to advance the organization.
- Demonstrates leadership and a commitment to organizational values. Takes ownership and has a strong sense of personal accountability. Consistently achieves or exceeds goals and expectations. Puts significant emphasis on living / upholding company values.
Compensation, Benefits, and So Much More - The expected salary range for this role based on the primary location for this position in California is $260,000 - $330,000 per year. Offer amounts are determined by factors such as experience, qualifications, geographic location, and other job-related factors permitted by law.
- A great environment where we work collaboratively, leverage each other's strengths, and work toward a shared vision with our common goals of doing the best thing for patients.
- A robust and enduring approach to your development and career growth fueled by a strong learning curriculum and career guidance that helps you understand how you can grow your career at CytomX.
- A robust and highly competitive total rewards program that helps you achieve your compensation goals while supporting a great work / life balance.
Conditions of Employment - Background investigations are required for all positions at CytomX, consistent with applicable law.
