We are seeking a highly motivated and solutions-oriented RWE Sr. Data Scientist I with experience and interest in oncology and epidemiological study design to join our team. This role requires the ability to lead observational studies, derive insights from complex real-world clinical data, implement advanced statistical methods, and leverage cutting-edge AI tools to scale tasks and augment insights.  Key Responsibilities • Pharma Collaboration & Strategy: Lead the design and execute delivery of RWE analyses for key pharma clients. You will be responsible for translating complex drug development questions and into actionable research plans that use Tempus data for trial design and outcomes research. • Real World Data Expertise: Lead the derivation of complex real-world endpoints using extensive coding, demonstrating deep comprehension of Tempus clinical and molecular data structures and complexity, while also serving as an expert on the methodological nuances and limitations of real-world data.  • Methodology & Platform Contribution: Build technical standards for the team, staying up-to-date on methodological advancements in real-world studies (e.g., causal inference, survival analysis) and oncology guidelines (NCCN and ongoing clinical trials). Contribute to reusable code and internal packages that can be applied across multiple collaborations. • AI & LLM Innovation: Incorporate LLMs, agentic workflows  and other AI tools into day-to-day workflows to accelerate code development, discovery, documentation, review, and insight generation.  • Scientific Interpretation & Communication: Interpret results of RWE analyses to draw appropriate inferences based on study design/statistical methods, while also evaluating study limitations. Communicate complex methods and results clearly to both technical and non-technical stakeholders. Prepare and present internal reports, external-facing deliverables, and, where appropriate, manuscripts or conference materials. • Cross-Functional Collaboration: Collaborate with internal product, oncology, and clinical abstraction, and real-world data science teams to continually enhance Tempus data quality, products, and analytical best practice. You will proactively identify gaps in current products and ensure that customer feedback is represented in development of new products.  • Oncology & RWE Domain Expertise: Grow and maintain deep expertise in oncology clinical guidelines (e.g., NCCN) and emerging RWE methodologies.  Minimum Qualifications • Education: Education in epidemiology, biostatistics, data science, public health, or a related field, to the level of either: - PhD and 2+ years of additional work experience - Master’s degree and 4+ years of additional work experience • Technical and Statistical Proficiency - Expert-level proficiency with observational real-world healthcare data, including analytical experience with time-to-event methodologies (survival analysis).  - Proven expertise in executing RWD analytical studies. - Proficient in using R and SQL, especially statistical tools and packages. - Proficiency applying machine learning, LLM-based coding assistants (e.g., Claude Code, Copilot, Cursor) and agentic frameworks to support data analysis, code review, or scientific documentation workflows. - Adherence to good software engineering practices (version control, modular code, documentation). - Experience with code review.  • Communication & Client Focus: Demonstrated experience interfacing with clients, showcasing adeptness in presenting and tailoring messaging to a variety of stakeholders. • Soft Skills: Excellent written and verbal communication skills with strong project management skills. Ability to thrive in a fast-paced, dynamic environment working with multi-disciplinary scientists on complex problems. Preferred Skillsets • Experience working with Pharma or drug development. • Experience in clinical trial design (particularly Phase II-III) in the clinical development space. • Analytical proficiency with claims, EHR, or registry data. • Practical experience building, fine-tuning, or configuring LLM-based tools and agentic workflows specifically for scientific discovery. • Knowledge of oncology guidelines (e.g., NCCN). • Significant experience analyzing biomarker, genomic, or other high-dimensional molecular data alongside clinical datasets. • Experience with cloud platforms such as AWS and/or BigQuery and/or Google Cloud Platform (GCP). #LI-DA1 CHI: $120,000-$170,000 NYC/SF: $130,000-$180,000 The expected salary range above is applicable if the role is performed from California and may vary for other locations (Colorado, Illinois, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.