Site: The General Hospital Corporation
Job SummaryThe Immunogenetics and Transplant Diagnostics (ITD) service currently operates across two laboratory sites, one at each academic medical center. Together, the BWH Tissue Typing and MGH Histocompatibility laboratories provide comprehensive support for solid organ (kidney, heart, lung, liver, pancreas), as well as hematopoietic progenitor cell transplantation and specialized non-transplant diagnostic testing. ITD performs ~60,000 HLA/histocompatibility-related tests per year. Collectively, the ITD laboratories support the combined Mass General Brigham transplant programs which performed more than 750 organ transplants in 2025 alone. In addition, the MGB ITD Service serves is the Organ Procurement Organization histocompatibility laboratory for OPTN Region 1 and supports nine additional organ and HPCT transplant hospitals across New England. The senior clinical manager will partner with ITD and MGB Pathology leadership to build a fully integrated immunogenetics laboratory.
Summary
Responsible for the daily operation of the lab: staffing, workflow, quality, safety, and regulatory compliance. The position provides daily management and strategic direction for the laboratories. Ensures compliance with all relevant federal, state, and accreditation requirements. This role oversees operations at multiple sites and requires strong management skills, as well as a collaborative approach when working with leaders both locally and within the system. This is an on-site role, rotating sites as operational and situational needs require.
Does this position require Patient Care?
No
Essential Functions
Develops and maintains QA systems to ensure a high level of performance and effective remedial actions to address deviations from performance specifications.
Review performance information, identify opportunities for improvement, and take action to eliminate root causes of performance that do not meet expectations.
Review event management reports, investigate complaints or problems, and analyze data to identify trends or patterns.
Ensure a validation protocol and validation summary is created for new or changed processes.
Assigns, monitors, and supervises work to ensure compliance with laboratory SOPs and applicable federal, state, and accreditation requirements, including health/safety and patient confidentiality.
Ensures the laboratory is prepared for all regulatory reviews and inspections (e.g., TJC, CAP, FACT).
Oversees the coordination of clinical trials with principal investigators, study coordinators, quality assurance, and compliance.
Manages computer systems to access clinical laboratory results, produce worksheets on components processed, and perform other data collection or analysis activities.
Conducts interviews and recommends candidates for hiring in accordance with departmental policies to ensure adequate staffing for the laboratory.
Responsible for staff orientation, training, competency assessment, and continuing education, including required department training (safety, infection control, compliance).
QualificationsRequired Experience The successful applicant must meet CLIA qualifications for general supervisor for high complexity laboratory performing histocompatibility testing (CFR § [redacted]), ASHI standard E.5.1, as well as OPTN and the Massachusetts Department of Health regulations. The ideal candidate will also demonstrate experience and success with the following:
- Progressive operational leadership experience managing large, complex histocompatibility laboratories supporting multi-hospital transplant programs and organ procurement organizations (OPO). Knowledge of OPTN Region 1 operations is critical.
- Proven successs overseeing all aspect of high-volume, 24/7 laboratory operations including staffing, workflow optimization, quality management, turnaround time, regulatory compliance, competency assessment, delivery of key performance indicators (e.g. turnaround times), capital/equipment planning, and budgeting/financial stewardship.
- Experience partnering with Pathology and laboratory medical and clinical leadership to support multiple transplant programs and coordinate testing and reporting urgent, time-sensitive transplant and other clinical decisions.
- Exceptional communication and execution skills with demonstrated ability to communicate clearly across technical, clinical and executive stakeholders, establish accountability and ensure consistent follow-through on operational, quality and strategic priorities.
- Exceptional collaboration and relationship-building skills with a track record of working effectively with external partners including transplant physicians, surgeons, clinical care teams, OPO leaders, IT, billing and compliance, quality and administrative leaders to advance laboratory operational excellence
- Demonstrated success leading process improvement, technology implementation, assay implementation/validation, and operational change within a complex clinical laboratory environment.
- Broad technical expertise across the full scope of Histocompatibility testing, including:
- Next-generation sequencing (NGS)-based HLA typing
- HLA antibody identification and characterization
- Donor-specific antibody (DSA) testing
- Physical (flow and CDC) and virtual crossmatching
- Chimerism testing
- ABO testing
- Strong experience in workforce leadership including development of sustainable staffing models, mentoring, career development, performance management, scheduling, productivity, inventory management and resource allocation.
- Experience developing and maintaining comprehensive quality management systems, including proficiency testing, competency programs, corrective and preventative actions, document control and continuous improvement initiatives.
Expertise with laboratory information systems and the
integration of laboratory testing platforms/instrumentation, interfaces, and information technology solutions to support complex clinical workflows.
Education
Bachelor's Degree Laboratory Sciences required or Master's Degree Related Field of Study preferred
Can this role accept experience in lieu of a degree?
No
Licenses and Credentials
ASCP Certified Medical Technologist [MLT, MT, MLA, Histologists] - Generic - HR Only required
Experience
Lab experience 5-7 years required and Demonstrated leadership experience in hospital-based CLIA laboratory 3-5 years required
Knowledge, Skills and Abilities
- Detailed knowledge of all regulatory requirements, including CAP, Joint Commission, and CLIA.
- Expert knowledge of laboratory health and safety protocols.
- Strong innovative attributes to remain on top of technology shifts.
- Effective written and verbal communication skills.
- Read, write and comprehend English sufficiently to communicate with patients, laboratory and others.
- Strong knowledge of personnel and employment practices.
- Ability to effectively manage staffing levels and workloads.
- Ability to effectively interview and train new employees.
Additional Job Details (if applicable)Remote TypeOnsite
Work Location275 Charles Street
Scheduled Weekly Hours40
Employee TypeRegular
Work ShiftDay (United States of America)
Pay Range$99,632.00 - $126,027.20/Annual
Grade8
At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.
