The Targeted Protein Degradation (TPD) Proteomics Core in the Fischer Lab at Dana-Farber Cancer Institute supports Cancer Biology researchers by using mass spectrometry-based proteomics to address important scientific questions. The core applies quantitative chemoproteomics and interaction proteomics to uncover drug targets and continues to broaden its capabilities to serve a growing research community. Its instrumentation includes advanced platforms such as the timsTOF HT, timsTOF Ultra2, and Orbitrap Eclipse Tribrid mass spectrometers.
We are seeking a driven and collaborative Scientist I / Research Scientist to join the TPD Core team. In this role, the scientist will use mass spectrometry technologies to study proteome-wide cellular responses to external perturbations and contribute to projects centered on targeted protein degradation as an emerging therapeutic strategy. Candidates with diverse mass spectrometry experience are encouraged to apply, with particular interest in individuals who bring expertise in laboratory automation, instrument operations, systems oversight, and proteomics workflow development.
- Lead the design and execution of proteomics experiments (eg, TMT, DIA, DDA) in collaboration with internal and external investigators
- Develop and implement automated workflows for sample preparation, instrument scheduling, data acquisition, and analysis across multiple platforms.
- Manage and maintain mass spectrometry instrumentation, including calibration, performance monitoring, and preventive maintenance to ensure high-throughput reliability.
- Integrate laboratory robotics and liquid handling systems into proteomics sample preparation pipelines to enhance throughput and reproducibility.
- Develop, optimize, and troubleshoot sample preparation workflows including whole cell proteomics, interactome analysis, and various enrichment protocols
- Analyze data using advanced pipelines (eg, DIA-NN, spectronaut, proteome discoverer) and support biological interpretation.
- Train and mentor junior staff and contribute to a culture of continuous improvement
- Ensure compliance with lab safety, QC standards, and data integrity policies
- Communicates with purchasing and may be responsible for negotiating with vendors
QUALIFICATIONS
- Ph.D in biochemistry, analytical chemistry, bioengineering or related field.
- Strong expertise in mass spectrometry-based proteomics and data analysis
- Hands on experience operating Thermo and/or Bruker mass spectrometers is required
- Demonstrated experience with laboratory automation, robotics, or pipeline development (e.g., Hamilton, Opentrons, or custom scripting for workflow automation).
- Proficiency with quantitative proteomics (label-free, TMT, DIA) and enrichment techniques.
- Familiarity with data analysis software and scripting (DIA-NN, Proteome Discoverer, R, Python).
- Excellent organizational, troubleshooting, and communication skills.
- Proven ability to work collaboratively across interdisciplinary teams and manage multiple projects simultaneously.
License/Certification/Registration Required: None
Supervisory Responsibilities: No
Patient Contact: None
The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications.
For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA).
$80,000.00 - $95,900.00
