PhD in Cancer Biology, Molecular Biology, or related fields.
Hands-on experience with mouse models of disease, particularly oncology.
Proven ability to independently plan and execute in-vivo studies and analyze data.
Skilled in mammalian cell culture and molecular biology techniques.
Responsibilities
Design and execute in-house animal experiments in mice.
Propose, plan, and coordinate toxicity, pharmacology, and efficacy studies at CROs.
Perform in vitro experiments to characterize candidate RNAs' mechanisms and potency.
Provide in vivo pharmacology and physiology expertise to accelerate tRNA therapeutic development.
Benefits
Medical, dental, and vision coverage.
401k retirement plan with employer match.
A stimulating, collegial, and fast-paced work environment.
Full Job Description
The Job
We are seeking an experienced in vivo Scientist to join our team. In this position, you will work in close conjunction with our founding team in the creation and development of a completely novel family of RNA therapeutics.
Your responsibilities will include designing and executing in house animal experiments in mice, proposing, planning and coordinating toxicity, pharmacology and efficacy studies at CROs, performing in vitro experiments to characterize the mechanism and potency of candidate RNAs, and providing in vivo pharmacology and physiology expertise to accelerate development of our tRNA therapeutics.
When & Where
Location: Boston, MA
Work Model: Full-time onsite
Qualifications:
PhD in Cancer Biology, Molecular Biology, or related fields.
Must have hands-on experience with mouse models of disease (preferably oncology), tissue collection and processing, and routine drug administration including intravenous and subcutaneous injections.
Demonstrated ability to independently plan and execute in-vivo studies, data analysis and interpretation.
Skilled in mammalian cell culture and molecular biology techniques.
Nice to haves:
Strong molecular/cell biology experience, particularly in immunology, RNA biochemistry and/or protein biochemistry.
Hands-on experience with flow cytometry, IHC, ELISA.
Experience with design/development RNA therapeutics and lipid nanoparticles.
Previous experience selecting and overseeing work at CROs.
Benefits:
Competitive salary commensurate with experience and strong equity incentives.
Medical, dental, and vision coverage.
401k retirement including employer match.
A stimulating, collegial, and fast-paced environment.
