PhD in Biochemistry or relevant discipline with 3+ years industry experience, or exceptional candidates with deep bench experience.
Strong background in biophysical and analytical characterization of antibodies and antibody fragments.
Proven ability to translate complex data into actionable results and recommendations.
Experience with protein structures and antibody engineering.
Eager to learn and integrate new technologies to enhance workflows and efficiency.
Preferred: prior experience in a dynamic start-up environment and with automation.
Responsibilities
Lead developability R&D projects, optimizing high throughput assays for the Milliner Platform.
Perform developability assessments on purity, stability, and biophysical properties of antibody candidates.
Support late-stage characterization and IND-enabling studies to rank and advance lead candidates.
Act as the Developability lead within project teams, guiding experimental strategies.
Collaborate cross-functionally to automate methodologies and monitor assay performance.
Analyze data independently, propose next steps, and communicate findings clearly.
Benefits
Multiple health insurance plan options through Anthem and Kaiser with a monthly credit for waived benefits.
Dental and vision coverage through Guardian.
Well-being benefits available through various platforms like Nayya and OneMedical.
401(k) plan with company match.
Diverse time off policy including DTO, two weeks of company-wide shutdown, and 12 holidays.
Paid parental leave.
Full Job Description
Scientist II, Developability
Department: Lab Science
Employment Type: Full Time
Location: San Mateo, CA
Description
The Role: BigHat Biosciences is looking for a hands-on, bench-driven scientist to drive antibody developability assessments that advance our Milliner Platform for AI-designed therapeutics. This is a primarily lab-based role where you'll spend the majority of your time at the bench executing and innovating on our developability workflows.
*At BigHat we believe in titles that commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that
responsibilities and title would adjust as appropriate.
Key Responsibilities
Lead developability R&D projects: design, optimize, and execute high throughput developability assays to expand BigHat's toolkit.
Drive developability assessments (purity, stability, tolerability, biophysical properties) across programs, with strong attention to data interpretation and organization.
Support late-stage characterization and IND-enabling studies, including formulation screening, stress testing, peptide mapping, and simulated administration studies, to rank and advance lead candidates.
Serve as the Developability lead within project teams, guiding experimental strategy to address liabilities and hit program milestones.
Work cross-functionally to automate and train colleagues on new and existing methods, build QC frameworks for monitoring assay performance, and adapt workflows to existing LIMS infrastructure.
Proactively and independently analyze data, interpret scientific findings, propose next steps, and broadcast findings clearly across the organization.
Skills Knowledge and Expertise
PhD in Biochemistry or relevant discipline with 3+ year(s) of industry experience; exceptional non-PhD candidates with deep bench experience will be considered.
Strong background in biophysical and analytical characterization of antibodies and antibody fragments: SEC, HIC, CE-SDS, DLS, DSF, ELISA, LC-MS, including method development and optimization.
Track record of translating complex data into clear results and recommended actions.
Experience with protein structures and antibody engineering.
Enthusiastic about learning and onboarding new technologies to expand capabilities and improve work quality, timelines, throughput or cost.
Nice-to-haves include prior experience working in a dynamic start-up environment, working as a project lead, and working with automation.
Total Rewards
The salary estimated for this position is $145,000 - $165,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
What BigHat Offers:
Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
Dental, and vision coverage through Guardian
Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
401(k) with company match
DTO, two weeks of company-wide shutdown, and 12 company holidays
Paid parental leave
About BigHat Biosciences
BigHat Biosciences is a biotechnology company that develops protein therapeutics using machine learning. The company's platform enables the rapid design and optimization of protein therapeutics, and is used to develop treatments for a variety of diseases, including cancer and autoimmune disorders. BigHat's technology is designed to be scalable, efficient, and cost-effective, and is used by pharmaceutical companies and academic researchers.
