Advances Denali’s oligonucleotide therapeutic pipeline by generating the in vivo and ex vivo evidence that guides candidate selection. Applies animal models, molecular and cellular assays, and pharmacokinetic and pharmacodynamic (PK/PD) studies to validate targets, identify biomarkers, and inform therapeutic development. Partners with Preclinical Translational Sciences, Developmental Sciences, Safety, and drug metabolism and pharmacokinetics (DMPK) scientists to move candidates through preclinical development. Delivers well-documented results that inform central nervous system (CNS) drug delivery and disease research decisions.
Key Accountabilities/Core Job Responsibilities:
- Design and execute in vivo and ex vivo studies that inform candidate progression, PK/PD modeling, and biomarker strategies
- Generate PK/PD data in preclinical models in partnership with Safety and DMPK scientists
- Perform molecular and biochemical assays, including RNA extraction, quantitative PCR, tissue sectioning, immunofluorescence, microscopy, and ELISAs
- Troubleshoot technical issues to keep experiments on schedule
- Evaluate oligonucleotide therapeutic candidates in CNS tissue-based models
- Analyze and interpret experimental data and report quantitative results
- Document experiments completely in electronic lab notebooks
- Present experimental designs and study results to cross-functional teams and collaborators
- Apply emerging scientific literature and technologies in CNS drug delivery and disease research to study design
Qualifications/Skills:
- Typically requires a PhD in Neuroscience, Cell Biology, Pharmacology, or a related scientific field; or a Master’s degree and 3+ years of relevant experience in academia or pharmaceutical discovery/translational research
- Hands-on proficiency in wet lab techniques (for example RNA extraction, quantitative PCR, tissue sectioning, immunofluorescence, microscopy, and ELISAs)
- Experience with in vivo models and CNS tissue-based studies
- Strong scientific reasoning in experimental design and data analysis
- Strong verbal and written communication skills, with the ability to work independently, prioritize tasks, and adapt in a fast-paced research environment
Salary Range: $110,000.00 to $143,000.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers
This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.
