Scientist, Cell Biology

Build human cell models and multiplexed high-content assays that reveal how drugs cause toxicity and predict their effects in people. Partner with robotics engineers, computational scientists, and ML researchers to generate large-scale biological datasets that power frontier AI agents for translational drug discovery. What you will do: • Build human cell models that accurately predict drug-induced toxicity in the liver, kidney, heart, immune system, and pharmacokinetics like exposure and metabolisms. • Design and optimize physiologically relevant systems using primary human cells, multicellular cultures, organoids, and other advanced models. • Develop high-content assays that reveal how drugs disrupt cellular function and cause injury. • Combine live-cell imaging, transcriptomics, proteomics, and mass spectrometry to connect changes in cell behavior with underlying molecular mechanisms. • Work with robotics engineers to build a generalizable robotics platform for assay development and turning complex assays into reproducible, high-throughput experimental workflows. • Establish rigorous validation and quality control standards to ensure consistent results across cell batches, plates, operators, and laboratories. • Investigate mechanisms of drug-induced injury and design experiments that distinguish meaningful biological effects from measurement artifacts. • Partner with computational scientists and drug discovery teams to generate large-scale biological datasets with the quality and depth needed to predict toxicity and guide drug development. • Partner with leading pharmaceutical companies and AI labs to interpret Axiom's data, uncover the biochemical mechanisms behind observed effects, and guide drug discovery decisions. What we look for: • You're an exceptional experimental scientist with a deep understanding of cell biology and human physiology. • You invent and refine biological models and assays to answer questions that established protocols cannot. • You care deeply about reproducibility, biological relevance, and data quality, with the attention to detail needed to catch subtle sources of error. • You hold your work to extremely rigorous scientific standards, designing decisive experiments with strong controls and drawing conclusions supported by the evidence. • You can interpret complex biological phenotypes and distinguish meaningful effects from noise, confounding factors, and experimental artifacts. • You challenge the limits of conventional cell models and develop systems that better predict human biology and drug responses. • You're deeply curious about cell biology, experimental technologies, and drug discovery, and eager to master new methods. • You communicate complex science clearly, make a compelling case for your ideas, and inspire scientists and collaborators to pursue ambitious questions. Technical skills we value: • Experience with primary human cell culture, iPSC culture and differentiation, and cell engineering. • Experience developing physiologically relevant models, including co-cultures, organoids, spheroids, and engineered tissues. • A strong foundation in cell biology, molecular biology, physiology, and pharmacology. • Expertise in high-content imaging, Cell Painting, fluorescence microscopy, live-cell imaging, and image-based phenotypic screening. • Experience developing, miniaturizing, and automating assays for high-throughput screening. • Experience measuring cell viability, mitochondrial function, oxidative stress, ER stress, apoptosis, inflammation, and other functional responses. • Familiarity with RNA sequencing, proteomics, metabolomics, and methods that combine multiple biological measurements. • Strong experimental design and quantitative analysis skills, including dose-response analysis, statistical methods, assay validation, and quality control.