Position Title: Research Associate II, High-Throughput Screening
Reports To: Director, Platform
Location: Watertown, MA
The successful candidate will execute, optimize, and automate existing in vitro screening workflows, culture relevant cell models, generate high-quality molecular data, and collaborate with Discovery, Chemistry, and Data Science colleagues. This role is ideal for a hands-on scientist who combines careful experimental execution with strong organization, curiosity, creativity, and teamwork.
Key Responsibilities:- Plan and execute high-throughput in vitro screens supporting Platform and Discovery efforts to identify ASO candidates that modulate expression of disease-relevant genes
- Operate liquid-handling platforms and associated laboratory automation with a strong focus on accuracy, reproducibility, and throughput
- Culture, maintain, and experimentally manipulate immortalized, primary, and iPSC-derived cell models
- Perform molecular assays, including RNA isolation, quantitative PCR, digital PCR (dPCR), and protein-based readouts
- Analyze screening data, assess assay quality, identify trends, and communicate results to cross-functional project teams
- Develop, optimize, qualify, troubleshoot, and transfer screening assays, workflows, protocols, and data quality controls to drive improvements in efficiency and capabilities
- Collaborate with Platform, Discovery, Chemistry, and Data Science teams to manage screening priorities and advance hits through validation and characterization
- Maintain detailed and accurate records of experimental designs and results, protocols, sample inventories, and data files
- Support routine laboratory operations, including reagent and supply ordering and preparation, equipment maintenance, and general laboratory upkeep
- Demonstrate a strong work ethic by taking initiative, operating with urgency, and collaborating effectively to advance the discovery of breakthrough medicines for patients
Qualifications:Education & Experience
- BS or MS degree in molecular biology, biochemistry, cell biology, bioengineering, or related discipline
- Relevant research experience in an industry or academic setting (3+ years with BS degree or 1+ year with MS degree); biotechnology or pharmaceutical industry experience is preferred
Skills & Competencies
- Extensive hands-on experience with mammalian cell culture and cell-based assays
- Experience with basic molecular biology techniques including RNA isolation, quantitative PCR, and western blotting
- Demonstrated ability to execute experiments carefully, document work thoroughly, and deliver reproducible results
- Experience with liquid-handling automation and high-throughput screening is strongly preferred
- Experience with primary cells, differentiated iPSC-derived cells, dPCR, and ASOs, or other oligonucleotide therapeutics is a plus
- Experience with functional genomics or CRISPR-based screening is a plus
- Working proficiency with Microsoft Office, GraphPad, R, or a similar software
- Flexibility and comfort wearing multiple hats and executing on multiple projects in parallel
- Attention to detail, high professional integrity, commitment to excellence in execution, and capability of managing tasks and projects independently
- Clear written and verbal communication skills and the ability to present data to multidisciplinary audiences
- Collaborative, creative, adaptable, and self-motivated, with a commitment to scientific rigor and high-quality execution
Compensation and Benefits:At CAMP4 Therapeutics, we offer a competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is $85,000 - $110,000. Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. In addition to base salary, employees are eligible to receive an annual bonus and equity incentive opportunities.
Our benefits include medical, dental, and vision insurance; life and disability coverage; paid parental leave; a 401(k) plan with company contribution; Employee Stock Purchase Program, Trek Time (flexible time off); tuition assistance; and additional perks that support your well-being and professional growth.
