AbbVie

Principal Research Scientist I, Multispecifics Engineering

AbbVie • $130K — $155K *
Pharmaceuticals & Biotech
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • PhD or MS in Biochemistry, Biochemical Engineering, or related field.
  • 6+ years (PhD) or 12+ years (MS) of experience in multispecific or antibody engineering.
  • Proven expertise in the design, expression, and purification of proteins and biologics.
  • Deep understanding of multispecific design trends across therapeutic areas such as immunology, oncology, and neuroscience.
  • Strong organizational skills with the ability to handle multiple projects efficiently.
  • Excellent communication skills and a collaborative team player attitude.

Responsibilities

  • Design and produce multispecific biologics for various therapy areas.
  • Act as the engineering representative and expert in cross-functional teams, providing updates and recommendations.
  • Manage project timelines as the Biologics Lead on 1-2 projects, ensuring smooth transitions from hit generation to candidate nomination.
  • Identify and resolve technical problems independently, implementing innovative research ideas.
  • Maintain high standards for the consistency and quality of technical reports.
  • Present research findings at scientific conferences and contribute to peer-reviewed publications.
  • Propose and develop new molecules that align with AbbVie's mission.

Benefits

  • Comprehensive medical, dental, and vision insurance.
  • Paid time off including vacation, holidays, and sick leave.
  • 401(k) retirement savings plan with company match.
  • Opportunity to participate in long-term incentive programs.
Full Job Description
The Multispecifics Engineering group at AbbVie is seeking a highly skilled, self-motivated scientist to join a dynamic team supporting Discovery Biotherapeutics. In this role, the successful candidate will drive the engineering, production, and characterization of multispecific biopharmaceutical products across multiple projects. The ideal candidate has extensive experience in biologics and multispecifics design, with a proven track record of applying multispecific engineering to advance discovery-stage programs, as well as experience in people and project management. We are looking for an enthusiastic, creative scientist ready to make tangible contributions to the pipeline. Key responsibilities: • Design, engineer, and produce multispecific biologics supporting multiple therapeutic areas. • Serve as the Multispecifics Engineering representative and subject matter expert on cross-functional teams-including Therapeutic Areas, Discovery Biotherapeutics, and Development Sciences-providing project updates, analysis, and recommendations. • Serve as Biologics Lead on 1-2 projects, managing molecule-related activities, building timelines with the TA Lead, contributing to key decision-making, and ensuring timely transitions from hit generation through candidate nomination. • Identify and solve technical problems independently; conceive and implement innovative research ideas that advance the group's and AbbVie's mission. • Ensure the consistency and quality of technical reports. • Present original work internally across departments and at internal and external scientific conferences; may author or co-author peer-reviewed papers or patents. Qualifications Minimum Qualifications: • PhD or MS degree in Biochemistry, Biochemical Engineering, or a related discipline. • 6+ (PhD) or 12+ (MS) years of experience in multispecific or antibody engineering • Experience with the design, expression, and purification of proteins, biologics, fragments, or multispecifics (e.g., bispecifics, trispecifics, bispecific protein fusions). • In-depth knowledge of the multispecific landscape, including design trends and technologies, and the application of the multispecific modality across therapeutic areas such as immunology, oncology, and neuroscience. • Ability to recognize emerging areas of interest in multispecific and antibody engineering and related fields, connecting research ideas to build next-generation molecules and advance platforms and programs. • Excellent organizational skills, with the ability to manage multiple projects simultaneously. • Strong team player able to operate effectively in a fast-paced, multidisciplinary environment. • Goal-oriented team player with excellent verbal and written communication skills and a strong can-do attitude. Preferred Qualifications: • Experience coordinating with CROs for protein production. • Expert understanding of protein expression, separation, and analytical technologies including mass spectrometry analysis of multispecifics. • Experience with technologies beyond recombinant protein production for generating multispecifics, enabling high-throughput screening to support agonist programs or screen combinatorial multispecific space (e.g. mammalian display). • Knowledge of biologic pipeline progression from exploratory through candidate nomination; program management experience preferred. Key AbbVie Competencies: • Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance. • Learns fast, grasps the "essence" and can change the course quickly where indicated. • Raises the bar and is never satisfied with the status quo. • Creates a learning environment, open to suggestions and experimentation for improvement. • Embraces the ideas of others, nurtures innovation and manages innovation to reality. • Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day) • Experience managing direct reports, including performance evaluations and development planning. • Recognized in the scientific community through a sustained record of peer-reviewed publications and patents. Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. • This job is eligible to participate in our long-term incentive programs. Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.

About AbbVie

AbbVie develops pharmaceuticals and medical devices. They provide products and services to therapeutic areas including immunology, oncology, neuroscience, eye care, virology, women's health, and gastroenterology.

AbbVie Careers

Joining AbbVie means becoming part of a global team dedicated to making a remarkable impact on patients' lives. At AbbVie, our employees are united in the pursuit of groundbreaking innovation and are committed to transforming the future of healthcare with leading-edge science.

Work You’ll Do

At AbbVie, you’ll collaborate with some of the brightest minds in the industry to solve challenging problems that have a high impact on society. Our culture fosters growth and embraces leadership and diversity training, ensuring that every team member can thrive.

Explore Job Opportunities

AbbVie offers a wide range of job opportunities and career paths, providing a platform where professionals can propel their careers forward. From research and development to marketing and sales, the potential to make a significant impact is limitless.

Internship Programs

Kickstart your career with an AbbVie internship. Our programs provide invaluable industry experience and a chance to develop essential skills in a real-world setting. Interns at AbbVie are considered integral members of the team and are given tasks that are both challenging and rewarding.

Professional Growth and Development

We believe in nurturing our team's professional growth through comprehensive training programs, leadership development opportunities, and continuous learning. Our commitment to your career growth is reflected in our robust offerings that enhance your skills and knowledge.

Benefits and Culture

AbbVie is dedicated to supporting our employees' well-being both inside and outside of work. Our benefits package includes health, financial, and social benefits that are designed to support the diverse needs of our employees. Our inclusive culture encourages collaboration and innovation, fostering a workplace where all can excel.

Hiring Process

Our hiring process is designed to ensure a match that will be beneficial both for the company and for your career aspirations. From resume submission to interview, each step is an opportunity to showcase your skills and fit with the AbbVie team.

Networking and Career Advancement

At AbbVie, networking doesn’t just enhance your career; it propels it. We encourage our employees to engage internally and externally to build relationships that foster personal and professional growth.

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Whether you’re seeking to advance your career in a dynamic and empowering environment, or looking for a place where you can innovate, lead, and contribute to something bigger, AbbVie is the place for you. Join us in our mission to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow.
Learn more about AbbVie
Size
50,000 employees
Market Cap
$288.5 billion
Industry
Net Income
$4.6 billion
Founded
2013
5 Year Trend
+17%
Revenue
$45.8 billion
NASDAQ

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