MD or DO with a background in Internal Medicine, Family Medicine, or a Specialist.
Active, unrestricted Pennsylvania medical license.
Prior clinical research experience as a Principal Investigator or Sub-Investigator.
Strong clinical judgment and commitment to participant safety.
Interest in clinical research and advancing medical innovation.
Ability to review structured clinical data and study-specific medical information.
Strong communication and documentation skills.
Responsibilities
Provide medical oversight and clinical leadership for clinical trials, ensuring patient safety and data quality.
Serve as the study physician, reviewing participant eligibility and overseeing screening outcomes.
Review adverse events and participant safety trends.
Perform or oversee study-specific medical assessments, including histories and physical exams.
Offer clinical guidance to Sub-Investigators and site staff.
Collaborate with study sponsors, CROs, and company leadership throughout trials.
Participate in site initiation, monitoring visits, and close-out activities.
Benefits
Health and welfare benefits coverage options including medical, dental, and vision.
Spending accounts and life insurance options.
Voluntary plans available.
Participation in a 401(k) plan.
Full Job Description
Job Title: Principal Investigator (MD/DO) Location: Pittsburgh, PA Type: Full-time
Overview We're seeking an experienced Principal Investigator (MD or DO) to support the growth and development of a new clinical research site. If you have prior experience serving as a Principal Investigator and are interested in expanding access to clinical research opportunities within the Pittsburgh community, we'd welcome the opportunity to connect!
Responsibilities
Provide medical oversight and clinical leadership for assigned clinical trials, ensuring patient safety and data quality.
Serve as the study physician, reviewing participant eligibility and providing medical oversight of screening outcomes.
Perform or oversee study-specific medical assessments, including histories, physical exams, and endpoint assessments.
Offer clinical guidance and oversight to Sub-Investigators, Clinical Research Coordinators, RNs, and site staff.
Collaborate with study sponsors, CROs, IRBs, and company leadership throughout each trial.
Participate in site initiation visits, monitoring visits, close-out activities, and other study meetings.
Review clinical data such as laboratory results, ECGs, vital signs, and other assessments.
Support timely safety reporting, medical documentation, and resolution of clinical data queries.
Maintain compliance with study protocols, SOPs, ICH-GCP, FDA regulations, and state requirements.
Contribute to a culture of quality, continuous improvement, and patient-centered research.
Requirements
MD or DO with a background in Internal Medicine, Family Medicine, or a Specialist.
Active, unrestricted Pennsylvania medical license.
Prior clinical research experience as a Principal Investigator, Sub-Investigator, or other clinical research physician.
Strong clinical judgment and commitment to participant safety.
Interest in clinical research and advancing medical innovation.
Ability to review structured clinical data and study-specific medical information.
Strong communication, documentation, and confidentiality practices.
Familiarity with ICH-GCP and FDA clinical research regulations.
Board certification.
DEA registration, if required by study protocols.
System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.
