PhD in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or related field with 0-2+ years of experience.
Experience with complex formulations and poorly behaved compounds.
Strong analytical skills, both conceptual and hands-on in the lab.
Familiarity with AI applications in scientific research.
Proficient in using GastroPlus or similar PBPK/PBBM software.
Experience in statistical analysis and data interpretation.
ELN experience, including developing standards and best practices.
Responsibilities
Design and develop complex formulations for various delivery methods.
Characterize poorly behaved compounds and devise strategies to enhance their properties.
Conduct compound risk assessments using physicochemical and performance data.
Design and interpret studies on solubility and stability of formulations.
Utilize analytical techniques to characterize compounds in the lab.
Employ PBPK and PBBM modeling tools to predict formulation performance.
Collaborate on innovative AI applications for new molecule development.
Benefits
Comprehensive medical coverage with dental and vision options.
Life and disability insurance.
401(k) plan with company match.
Paid holidays and vacation.
Full Job Description
Job Description
Eurofins PSS West is looking for a Principal Formulations Scientist to develop and characterize formulations on complex and poorly behaved drug candidates, advance data management and documentation practices, and partner in the innovative application of AI at a client site in San Diego, CA. This scientist combines hands-on lab skills with data-driven, modeling-based assessment of compounds. They are expected to work independently and act as a technical resource for the team.
Responsibilities include, but are not limited to:
Design and develop prototype and complex formulations (solutions, suspensions and enabling formulations) for oral, subcutaneous, and/or intravenous (sterile) delivery to support in-vitro and in-vivo studies.
Formulate and characterize poorly behaved compounds, including those with low solubility or poor stability, and develop strategies to overcome their limitations.
Contribute to compound risk assessments utilizing physicochemical property information, in vivo performance data, and predictive tools.
Design and interpret studies of solubility, chemical and physical stability, and in-vitro performance (non-sink dissolution, precipitation).
Apply analytical techniques (HPLC, DSC, PXRD, spectroscopy), both conceptually and in the lab, to characterize compounds and formulations.
Use physiologically based pharmacokinetic (PBPK) and physiologically based biopharmaceutics modeling (PBBM) tools such as GastroPlus to predict compound and formulation performance.
Partner in the novel application of AI in the advancement of new molecules.
Curate data from contract research organizations (CROs) and other external partners.
Write and review study protocols and technical reports.
Record work in an ELN, and help develop ELN standards and best practices.
Qualifications
The Ideal Candidate would possess:
Experience with complex formulations and with formulating and studying poorly behaved compounds
Experience performing compound risk assessments
Strong analytical skills, both conceptual and hands-on in the lab
Experience with prompting and the application of AI
Excellent communication, organization and attention to detail
Experience with GastroPlus or other PBPK/PBBM software
Experience with statistical analysis
ELN experience, including developing ELN standards
Basic Minimum Qualifications:
PhD in Pharmaceutical Sciences, Chemistry, Chemical Engineering or a related field, with 0-2+ years of related experience
Authorization to work in the United States indefinitely without restriction or sponsorship
Candidates within commuting distance of San Diego, CA are encouraged to apply
Additional Information
Comprehensive medical coverage, with dental and vision options
Life and disability insurance
401(k) with company match
Paid holidays and vacation
Compensation Range: $90,000-$115,000/yr
Eurofins Lancaster Laboratories Professional Scientific Services® (PSS) is a global, award-winning insourcing solution that places our people at our clients' site dedicated to running and managing laboratory services while eliminating headcount, co-employment and project-management worries.
We infuse our 55-year track record of scientific and laboratory operations expertise, as well as HR and great place to work best practices, to recruit, hire, train and manage highly qualified scientists to perform laboratory services using our client's quality systems and equipment.
We are looking forward to receiving your application including your expected salary and possible start date via our career website.
About Eurofins Lancaster Laboratories
Eurofins Lancaster Laboratories is a leading contract research organization (CRO) providing analytical, research and testing services to clients in the pharmaceutical, biopharmaceutical, biotechnology, crop protection, chemical, food, environmental and consumer products industries. The company was founded in 1961 and has grown to become one of the largest CROs in the world, with over 50 locations in 20 countries. Eurofins Lancaster Laboratories is part of the Eurofins Scientific Group, a global leader in bioanalytical testing and laboratory services. The company's services include method development and validation, stability testing, quality control testing, and regulatory compliance support.
